• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jclinpathJournal of Clinical PathologyVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Clin Pathol. Apr 1974; 27(4): 269–272.
PMCID: PMC478100

The effect of minocycline on Candida albicans


Minocycline, a new tetracycline derivative, was found to inhibit the growth of Candida albicans. Inhibition was much affected by the composition of the medium and was difficult to demonstrate in fluid cultures. Study of the rate of budding in shallow broth cultures in Petri dishes showed that the addition of 20 μg/ml minocycline prolonged the lag phase by three hours. C. tropicalis was similarly inhibited and C. guilliermondii and C. parapsilosis to a lesser degree. Six other tetracyclines were tested and found to inhibit Candida only in very high concentrations.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (958K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Martell MJ, Jr, Boothe JH. The 6-deoxytetracyclines. VII. Alkylated aminotetracyclines possessing unique antibacterial activity. J Med Chem. 1967 Jan;10(1):44–46. [PubMed]
  • Nicholls MW. Polymyxin sensitivity of Candida tropicalis. J Med Microbiol. 1970 Aug;3(3):529–538. [PubMed]
  • Steigbigel NH, Reed CW, Finland M. Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro. Am J Med Sci. 1968 Mar;255:179–195. [PubMed]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...