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J Clin Pathol. Apr 1974; 27(4): 269–272.
PMCID: PMC478100

The effect of minocycline on Candida albicans

Abstract

Minocycline, a new tetracycline derivative, was found to inhibit the growth of Candida albicans. Inhibition was much affected by the composition of the medium and was difficult to demonstrate in fluid cultures. Study of the rate of budding in shallow broth cultures in Petri dishes showed that the addition of 20 μg/ml minocycline prolonged the lag phase by three hours. C. tropicalis was similarly inhibited and C. guilliermondii and C. parapsilosis to a lesser degree. Six other tetracyclines were tested and found to inhibit Candida only in very high concentrations.

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Selected References

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  • Martell MJ, Jr, Boothe JH. The 6-deoxytetracyclines. VII. Alkylated aminotetracyclines possessing unique antibacterial activity. J Med Chem. 1967 Jan;10(1):44–46. [PubMed]
  • Nicholls MW. Polymyxin sensitivity of Candida tropicalis. J Med Microbiol. 1970 Aug;3(3):529–538. [PubMed]
  • Steigbigel NH, Reed CW, Finland M. Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro. Am J Med Sci. 1968 Mar;255:179–195. [PubMed]

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