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J Clin Pathol. Sep 1975; 28(9): 711–716.
PMCID: PMC475812

Lobular carcinoma of the breast: a special variant of mucin-secreting carcinoma.

Abstract

There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The same histochemical features are seen in the infiltrative phase of the tumour. These findings invalidate the concept that it is a myoepithelial-cell tumour. Practical applications of the distinctive pattern of mucin secretion are discussed.

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Selected References

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  • Carter D, Yardley JH, Shelley WM. Lobular carcinoma of the breast an ultrastructural comparison with certain duct carcinomas and benign lesions. Johns Hopkins Med J. 1969 Jul;125(1):25–32. [PubMed]
  • Fechner RE. Ductal carcinoma involving the lobule of the breast. A source of confusion with lobular carcinoma in situ. Cancer. 1971 Aug;28(2):274–281. [PubMed]
  • Foote FW, Stewart FW. Lobular carcinoma in situ: A rare form of mammary cancer. Am J Pathol. 1941 Jul;17(4):491–496.3. [PMC free article] [PubMed]
  • Gad A. A histochemical study of human alimentary tract mucosubstances in health and disease. I. Normal and tumours. Br J Cancer. 1969 Mar;23(1):52–63. [PMC free article] [PubMed]
  • Hamperl H. Zur Kenntnis des sog. Carcinoma lobulare in situ der Mamma. Beiträge zur pathologischen Histologie der Mamma. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1972;77(3):231–246. [PubMed]
  • Hutter RV, Snyder RE, Lucas JC, Foote FW, Jr, Farrow JH. Clinical and pathologic correlation with mammographic findings in lobular carcinoma in situ. Cancer. 1969 Apr;23(4):826–839. [PubMed]
  • Williams RJ, Wacker EC. Cation balance in biological systems. JAMA. 1967 Jul 3;201(1):96–100. [PubMed]
  • Newman W. Lobular carcinoma of the female breast. Report of 73 cases. Ann Surg. 1966 Aug;164(2):305–314. [PMC free article] [PubMed]
  • Toker C. Small cell dysplasia and in-situ carcinoma of the mammary ducts and lobules. J Pathol. 1974 Sep;114(1):47–52. [PubMed]
  • Warner NE. Lobular carcinoma of the breast. Cancer. 1969 Apr;23(4):840–846. [PubMed]
  • WELLINGS SR, ROBERTS P. Electron microscopy of sclerosing adenosis and infiltrating duct carcinoma of the human mammary gland. J Natl Cancer Inst. 1963 Feb;30:269–287. [PubMed]

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