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Thorax. Oct 1993; 48(10): 1034–1043.
PMCID: PMC464825

Nitric oxide and lung disease.

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Selected References

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  • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991 Jun;43(2):109–142. [PubMed]
  • Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992 Sep;6(12):3051–3064. [PubMed]
  • Barnes PJ. Nitric oxide and airways. Eur Respir J. 1993 Feb;6(2):163–165. [PubMed]
  • Jorens PG, Vermeire PA, Herman AG. L-arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways. Eur Respir J. 1993 Feb;6(2):258–266. [PubMed]
  • Furchgott RF. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol. 1984;24:175–197. [PubMed]
  • Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987 Jun 11;327(6122):524–526. [PubMed]
  • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9265–9269. [PMC free article] [PubMed]
  • Hibbs JB, Jr, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science. 1987 Jan 23;235(4787):473–476. [PubMed]
  • Iyengar R, Stuehr DJ, Marletta MA. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6369–6373. [PMC free article] [PubMed]
  • Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988 Jun 16;333(6174):664–666. [PubMed]
  • Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A. 1989 Nov;86(22):9030–9033. [PMC free article] [PubMed]
  • Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun. 1991 Dec 16;181(2):852–857. [PubMed]
  • Lowenstein CJ, Snyder SH. Nitric oxide, a novel biologic messenger. Cell. 1992 Sep 4;70(5):705–707. [PubMed]
  • Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A. 1990 Jan;87(2):682–685. [PMC free article] [PubMed]
  • Hope BT, Michael GJ, Knigge KM, Vincent SR. Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2811–2814. [PMC free article] [PubMed]
  • Hope BT, Vincent SR. Histochemical characterization of neuronal NADPH-diaphorase. J Histochem Cytochem. 1989 May;37(5):653–661. [PubMed]
  • Lamas S, Marsden PA, Li GK, Tempst P, Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6348–6352. [PMC free article] [PubMed]
  • Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 1992 Jul 25;267(21):14519–14522. [PubMed]
  • Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991 Jun 27;351(6329):714–718. [PubMed]
  • Schmidt HH, Murad F. Purification and characterization of a human NO synthase. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1372–1377. [PubMed]
  • Kwon NS, Nathan CF, Stuehr DJ. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem. 1989 Dec 5;264(34):20496–20501. [PubMed]
  • Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 1992 Apr 10;256(5054):225–228. [PubMed]
  • Lyons CR, Orloff GJ, Cunningham JM. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370–6374. [PubMed]
  • Di Rosa M, Radomski M, Carnuccio R, Moncada S. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun. 1990 Nov 15;172(3):1246–1252. [PubMed]
  • Radomski MW, Palmer RM, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci U S A. 1990 Dec;87(24):10043–10047. [PMC free article] [PubMed]
  • Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S. Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol. 1990 Aug 1;145(3):940–944. [PubMed]
  • Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol. 1990 Nov;101(3):746–752. [PMC free article] [PubMed]
  • Bogle RG, Moncada S, Pearson JD, Mann GE. Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter. Br J Pharmacol. 1992 Apr;105(4):768–770. [PMC free article] [PubMed]
  • Rajanayagam MA, Li CG, Rand MJ. Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle. Br J Pharmacol. 1993 Jan;108(1):3–5. [PMC free article] [PubMed]
  • Misko TP, Moore WM, Kasten TP, Nickols GA, Corbett JA, Tilton RG, McDaniel ML, Williamson JR, Currie MG. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol. 1993 Mar 16;233(1):119–125. [PubMed]
  • Lincoln TM. Cyclic GMP and mechanisms of vasodilation. Pharmacol Ther. 1989;41(3):479–502. [PubMed]
  • Garg UC, Hassid A. Nitric oxide decreases cytosolic free calcium in Balb/c 3T3 fibroblasts by a cyclic GMP-independent mechanism. J Biol Chem. 1991 Jan 5;266(1):9–12. [PubMed]
  • Gruetter CA, Barry BK, McNamara DB, Gruetter DY, Kadowitz PJ, Ignarro L. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res. 1979;5(3):211–224. [PubMed]
  • Myers PR, Minor RL, Jr, Guerra R, Jr, Bates JN, Harrison DG. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature. 1990 May 10;345(6271):161–163. [PubMed]
  • Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH. Carbon monoxide: a putative neural messenger. Science. 1993 Jan 15;259(5093):381–384. [PubMed]
  • Dinh-Xuan AT. Endothelial modulation of pulmonary vascular tone. Eur Respir J. 1992 Jun;5(6):757–762. [PubMed]
  • Crawley DE, Liu SF, Evans TW, Barnes PJ. Inhibitory role of endothelium-derived relaxing factor in rat and human pulmonary arteries. Br J Pharmacol. 1990 Sep;101(1):166–170. [PMC free article] [PubMed]
  • Altiere RJ, Thompson DC. Modulation of cholinergic responses by N omega-nitro-L-arginine in rabbit intrapulmonary arteries. Pulm Pharmacol. 1992 Jun;5(2):149–151. [PubMed]
  • Crawley DE, Liu SF, Barnes PJ, Evans TW. Endothelin-3 is a potent pulmonary vasodilator in the rat. J Appl Physiol (1985) 1992 Apr;72(4):1425–1431. [PubMed]
  • Liu SF, Crawley DE, Barnes PJ, Evans TW. Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis. 1991 Jan;143(1):32–37. [PubMed]
  • Persson MG, Gustafsson LE, Wiklund NP, Moncada S, Hedqvist P. Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol Scand. 1990 Dec;140(4):449–457. [PubMed]
  • Adnot S, Raffestin B, Eddahibi S, Braquet P, Chabrier PE. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest. 1991 Jan;87(1):155–162. [PMC free article] [PubMed]
  • Crawley DE, Zhao L, Giembycz MA, Liu S, Barnes PJ, Winter RJ, Evans TW. Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat. Am J Physiol. 1992 Sep;263(3 Pt 1):L325–L332. [PubMed]
  • Dinh-Xuan AT, Higenbottam TW, Clelland CA, Pepke-Zaba J, Cremona G, Butt AY, Large SR, Wells FC, Wallwork J. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N Engl J Med. 1991 May 30;324(22):1539–1547. [PubMed]
  • Dinh-Xuan AT, Higenbottam TW, Clelland CA, Pepke-Zaba J, Cremona G, Butt AY, Large SR, Wells FC, Wallwork J. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N Engl J Med. 1991 May 30;324(22):1539–1547. [PubMed]
  • Dinh Xuan AT, Higenbottam TW, Pepke-Zaba J, Clelland C, Wallwork J. Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries. Eur J Pharmacol. 1989 Apr 25;163(2-3):401–403. [PubMed]
  • Cremona G, Dinh Xuan AT, Higenbottam TW. Endothelium-derived relaxing factor and the pulmonary circulation. Lung. 1991;169(4):185–202. [PubMed]
  • Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation. 1991 Jun;83(6):2038–2047. [PubMed]
  • Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology. 1993 Mar;78(3):427–435. [PubMed]
  • Pison U, López FA, Heidelmeyer CF, Rossaint R, Falke KJ. Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange. J Appl Physiol (1985) 1993 Mar;74(3):1287–1292. [PubMed]
  • Grantham-McGregor SM, Powell CA, Walker SP, Himes JH. Nutritional supplementation, psychosocial stimulation, and mental development of stunted children: the Jamaican Study. Lancet. 1991 Jul 6;338(8758):1–5. [PubMed]
  • Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992 Oct 3;340(8823):818–819. [PubMed]
  • Rossaint R, Falke KJ, López F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993 Feb 11;328(6):399–405. [PubMed]
  • Alving K, Fornhem C, Weitzberg E, Lundberg JM. Nitric oxide mediates cigarette smoke-induced vasodilatory responses in the lung. Acta Physiol Scand. 1992 Nov;146(3):407–408. [PubMed]
  • Gruetter CA, Childers CE, Bosserman MK, Lemke SM, Ball JG, Valentovic MA. Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways. Am Rev Respir Dis. 1989 May;139(5):1192–1197. [PubMed]
  • Munakata M, Masaki Y, Sakuma I, Ukita H, Otsuka Y, Homma Y, Kawakami Y. Pharmacological differentiation of epithelium-derived relaxing factor from nitric oxide. J Appl Physiol (1985) 1990 Aug;69(2):665–670. [PubMed]
  • Högman M, Frostell C, Arnberg H, Hedenstierna G. Inhalation of nitric oxide modulates methacholine-induced bronchoconstriction in the rabbit. Eur Respir J. 1993 Feb;6(2):177–180. [PubMed]
  • Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM. Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest. 1992 Aug;90(2):421–428. [PMC free article] [PubMed]
  • Valentovic MA, Ball JG, Morenas M, Szarek JL, Gruetter CA. Influence of nitrovasodilators on bovine pulmonary histamine release. Pulm Pharmacol. 1992 Jun;5(2):97–102. [PubMed]
  • Foubert L, Fleming B, Latimer R, Jonas M, Oduro A, Borland C, Higenbottam T. Safety guidelines for use of nitric oxide. Lancet. 1992 Jun 27;339(8809):1615–1616. [PubMed]
  • Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science. 1992 Dec 18;258(5090):1898–1902. [PubMed]
  • Orehek J, Massari JP, Gayrard P, Grimaud C, Charpin J. Effect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients. J Clin Invest. 1976 Feb;57(2):301–307. [PMC free article] [PubMed]
  • Rasmussen TR, Kjaergaard SK, Tarp U, Pedersen OF. Delayed effects of NO2 exposure on alveolar permeability and glutathione peroxidase in healthy humans. Am Rev Respir Dis. 1992 Sep;146(3):654–659. [PubMed]
  • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620–1624. [PMC free article] [PubMed]
  • Rand MJ. Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission. Clin Exp Pharmacol Physiol. 1992 Mar;19(3):147–169. [PubMed]
  • Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 1990 Oct 25;347(6295):768–770. [PubMed]
  • Tucker JF, Brave SR, Charalambous L, Hobbs AJ, Gibson A. L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol. 1990 Aug;100(4):663–664. [PMC free article] [PubMed]
  • Li CG, Rand MJ. Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. Br J Pharmacol. 1991 Jan;102(1):91–94. [PMC free article] [PubMed]
  • Kannan MS, Johnson DE. Functional innervation of pig tracheal smooth muscle: neural and non-neural mechanisms of relaxation. J Pharmacol Exp Ther. 1992 Mar;260(3):1180–1184. [PubMed]
  • Kannan MS, Johnson DE. Nitric oxide mediates the neural nonadrenergic, noncholinergic relaxation of pig tracheal smooth muscle. Am J Physiol. 1992 Apr;262(4 Pt 1):L511–L514. [PubMed]
  • Fisher JT, Anderson JW, Waldron MA. Nonadrenergic noncholinergic neurotransmitter of feline trachealis: VIP or nitric oxide? J Appl Physiol (1985) 1993 Jan;74(1):31–39. [PubMed]
  • Belvisi MG, Stretton CD, Yacoub M, Barnes PJ. Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur J Pharmacol. 1992 Jan 14;210(2):221–222. [PubMed]
  • Belvisi MG, Stretton CD, Miura M, Verleden GM, Tadjkarimi S, Yacoub MH, Barnes PJ. Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter. J Appl Physiol (1985) 1992 Dec;73(6):2505–2510. [PubMed]
  • Ellis JL, Undem BJ. Inhibition by L-NG-nitro-L-arginine of nonadrenergic-noncholinergic-mediated relaxations of human isolated central and peripheral airway. Am Rev Respir Dis. 1992 Dec;146(6):1543–1547. [PubMed]
  • Rhoden KJ, Barnes PJ. Epithelial modulation of non-adrenergic, non-cholinergic and vasoactive intestinal peptide-induced responses: role of neutral endopeptidase. Eur J Pharmacol. 1989 Nov 21;171(2-3):247–250. [PubMed]
  • Watson N, Maclagan J, Barnes PJ. Vagal control of guinea pig tracheal smooth muscle: lack of involvement of VIP or nitric oxide. J Appl Physiol (1985) 1993 Apr;74(4):1964–1971. [PubMed]
  • Fischer A, Mundel P, Mayer B, Preissler U, Philippin B, Kummer W. Nitric oxide synthase in guinea pig lower airway innervation. Neurosci Lett. 1993 Jan 12;149(2):157–160. [PubMed]
  • Ignarro LJ, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ, Gruetter CA. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther. 1981 Sep;218(3):739–749. [PubMed]
  • Aoki E, Semba R, Kashiwamata S. Evidence for the presence of L-arginine in the glial components of the peripheral nervous system. Brain Res. 1991 Sep 13;559(1):159–162. [PubMed]
  • Chiu SY. Functions and distribution of voltage-gated sodium and potassium channels in mammalian Schwann cells. Glia. 1991;4(6):541–558. [PubMed]
  • Li CG, Rand MJ. Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus. Eur J Pharmacol. 1990 Dec 4;191(3):303–309. [PubMed]
  • Ward JK, Belvisi MG, Fox AJ, Miura M, Tadjkarimi S, Yacoub MH, Barnes PJ. Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro. J Clin Invest. 1993 Aug;92(2):736–742. [PMC free article] [PubMed]
  • Belvisi MG, Stretton D, Barnes PJ. Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways. Eur J Pharmacol. 1991 Jun 6;198(2-3):219–221. [PubMed]
  • Lei YH, Barnes PJ, Rogers DF. Regulation of NANC neural bronchoconstriction in vivo in the guinea-pig: involvement of nitric oxide, vasoactive intestinal peptide and soluble guanylyl cyclase. Br J Pharmacol. 1993 Jan;108(1):228–235. [PMC free article] [PubMed]
  • Kummer W, Fischer A, Mundel P, Mayer B, Hoba B, Philippin B, Preissler U. Nitric oxide synthase in VIP-containing vasodilator nerve fibres in the guinea-pig. Neuroreport. 1992 Jul;3(7):653–655. [PubMed]
  • Stretton CD, Mak JC, Belvisi MG, Yacoub MH, Barnes PJ. Cholinergic control of human airways in vitro following extrinsic denervation of the human respiratory tract by heart-lung transplantation. Am Rev Respir Dis. 1990 Nov;142(5):1030–1033. [PubMed]
  • Canning BJ, Undem BJ. Relaxant innervation of the guinea-pig trachealis: demonstration of capsaicin-sensitive and -insensitive vagal pathways. J Physiol. 1993 Jan;460:719–739. [PMC free article] [PubMed]
  • Lammers JW, Barnes PJ, Chung KF. Nonadrenergic, noncholinergic airway inhibitory nerves. Eur Respir J. 1992 Feb;5(2):239–246. [PubMed]
  • Rubanyi GM, Vanhoutte PM. Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. Am J Physiol. 1986 May;250(5 Pt 2):H815–H821. [PubMed]
  • Liu SF, Crawley DE, Evans TW, Barnes PJ. Endothelium-dependent nonadrenergic, noncholinergic neural relaxation in guinea pig pulmonary artery. J Pharmacol Exp Ther. 1992 Feb;260(2):541–548. [PubMed]
  • Liu SF, Crawley DE, Rohde JA, Evans TW, Barnes PJ. Role of nitric oxide and guanosine 3',5'-cyclic monophosphate in mediating nonadrenergic, noncholinergic relaxation in guinea-pig pulmonary arteries. Br J Pharmacol. 1992 Nov;107(3):861–866. [PMC free article] [PubMed]
  • Liu SF, Crawley DE, Evans TW, Barnes PJ. Endogenous nitric oxide modulates adrenergic neural vasoconstriction in guinea-pig pulmonary artery. Br J Pharmacol. 1991 Oct;104(2):565–569. [PMC free article] [PubMed]
  • Liu SF, Crawley DE, Evans TW, Barnes PJ. Endogenous nitric oxide modulates adrenergic neural vasoconstriction in guinea-pig pulmonary artery. Br J Pharmacol. 1991 Oct;104(2):565–569. [PMC free article] [PubMed]
  • Thornbury KD, Ward SM, Dalziel HH, Carl A, Westfall DP, Sanders KM. Nitric oxide and nitrosocysteine mimic nonadrenergic, noncholinergic hyperpolarization in canine proximal colon. Am J Physiol. 1991 Sep;261(3 Pt 1):G553–G557. [PubMed]
  • Kowaluk EA, Fung HL. Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols. J Pharmacol Exp Ther. 1990 Dec;255(3):1256–1264. [PubMed]
  • Gillespie JS, Sheng H. A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip. Br J Pharmacol. 1989 Oct;98(2):445–450. [PMC free article] [PubMed]
  • Tayeh MA, Marletta MA. Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. J Biol Chem. 1989 Nov 25;264(33):19654–19658. [PubMed]
  • Jorens PG, Van Overveld FJ, Bult H, Vermeire PA, Herman AG. L-arginine-dependent production of nitrogen oxides by rat pulmonary macrophages. Eur J Pharmacol. 1991 Aug 6;200(2-3):205–209. [PubMed]
  • Hibbs JB, Jr, Vavrin Z, Taintor RR. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol. 1987 Jan 15;138(2):550–565. [PubMed]
  • Cunha FQ, Moncada S, Liew FY. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1155–1159. [PubMed]
  • Assreuy J, Cunha FQ, Liew FY, Moncada S. Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br J Pharmacol. 1993 Mar;108(3):833–837. [PMC free article] [PubMed]
  • Salvemini D, Masini E, Anggard E, Mannaioni PF, Vane J. Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: stimulation of guanylate cyclase and inhibition of platelet aggregation. Biochem Biophys Res Commun. 1990 Jun 15;169(2):596–601. [PubMed]
  • McCall TB, Boughton-Smith NK, Palmer RM, Whittle BJ, Moncada S. Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. Biochem J. 1989 Jul 1;261(1):293–296. [PMC free article] [PubMed]
  • Nakayama DK, Geller DA, Lowenstein CJ, Chern HD, Davies P, Pitt BR, Simmons RL, Billiar TR. Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle. Am J Respir Cell Mol Biol. 1992 Nov;7(5):471–476. [PubMed]
  • Knowles RG, Merrett M, Salter M, Moncada S. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J. 1990 Sep 15;270(3):833–836. [PMC free article] [PubMed]
  • Robbins RA, Hamel FG, Floreani AA, Gossman GL, Nelson KJ, Belenky S, Rubinstein I. Bovine bronchial epithelial cells metabolize L-arginine to L-citrulline: possible role of nitric oxide synthase. Life Sci. 1993;52(8):709–716. [PubMed]
  • Jain B, Rubinstein I, Robbins RA, Leise KL, Sisson JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun. 1993 Feb 26;191(1):83–88. [PubMed]
  • Jorens PG, Van Overveld FJ, Vermeire PA, Bult H, Herman AG. Synergism between interleukin-1 beta and interferon-gamma, an inducer of nitric oxide synthase, in rat lung fibroblasts. Eur J Pharmacol. 1992 Nov 24;224(1):7–12. [PubMed]
  • Jorens PG, Van Overveld FJ, Vermeire PA, Bult H, Herman AG. Synergism between interleukin-1 beta and interferon-gamma, an inducer of nitric oxide synthase, in rat lung fibroblasts. Eur J Pharmacol. 1992 Nov 24;224(1):7–12. [PubMed]
  • Holt PG. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur Respir J. 1993 Jan;6(1):120–129. [PubMed]
  • Kawabe T, Isobe KI, Hasegawa Y, Nakashima I, Shimokata K. Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages. Immunology. 1992 May;76(1):72–78. [PMC free article] [PubMed]
  • Ialenti A, Ianaro A, Moncada S, Di Rosa M. Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol. 1992 Feb 11;211(2):177–182. [PubMed]
  • Kuo HP, Liu S, Barnes PJ. The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways. Eur J Pharmacol. 1992 Oct 20;221(2-3):385–388. [PubMed]
  • Mulligan MS, Hevel JM, Marletta MA, Ward PA. Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6338–6342. [PMC free article] [PubMed]
  • HIRSHLEIFER I, ARORA Y. Nitrites in the treatment of bronchial asthma. Dis Chest. 1961 Mar;39:275–283. [PubMed]
  • Jansen A, Drazen J, Osborne JA, Brown R, Loscalzo J, Stamler JS. The relaxant properties in guinea pig airways of S-nitrosothiols. J Pharmacol Exp Ther. 1992 Apr;261(1):154–160. [PubMed]
  • Van Snick J. Interleukin-6: an overview. Annu Rev Immunol. 1990;8:253–278. [PubMed]
  • Baudouin SV, Bath P, Martin JF, Du Bois R, Evans TW. L-arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance. Br J Clin Pharmacol. 1993 Jul;36(1):45–49. [PMC free article] [PubMed]
  • Rees DD, Palmer RM, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989 May;86(9):3375–3378. [PMC free article] [PubMed]

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