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Thorax. Mar 1985; 40(3): 187–190.
PMCID: PMC460025

Serum concentrations of vitamin D metabolites in untreated tuberculosis.

Abstract

A prospective study of 50 consecutive patients presenting with tuberculosis has shown that patients have on average lower serum concentrations of 25-hydroxycholecalciferol (25-OHD) than healthy matched controls. No difference was shown in serum 1,25-(OH)2D, 24,25-(OH)2D, or parathyroid hormone. Uncorrected serum calcium was lower in the patient group but identical when correction concentrations were made for albumin. Serum liver enzyme concentrations were significantly higher in the patient population. Low serum vitamin D concentrations may be a consequence of disease. The possibility that low serum 25-OHD concentrations may predispose to tuberculosis infection cannot, however, be excluded. Prolonged treatment with isoniazid or rifampicin, both of which have been shown to reduce serum 25-OHD, may increase the risk of vitamin D deficiency and consequent osteomalacia in groups of patients most at risk, such as those of Indian subcontinental ethnic origin.

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Selected References

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  • DUNNIGAN MG, PATON JP, HAASE S, McNICOL GW, GARDNER MD, SMITH CM. Late rickets and osteomalacia in the Pakistani community in Glasgow. Scott Med J. 1962 Apr;7:159–167. [PubMed]
  • Ford JA, Colhoun EM, McIntosh WB, Dunnigan MG. Rickets and osteomalacia in the Glasgow Pakistani community, 1961-71. Br Med J. 1972 Jun 17;2(5815):677–680. [PMC free article] [PubMed]
  • Hunt SP, O'Riordan JL, Windo J, Truswell AS. Vitamin D status in different subgroups of British Asians. Br Med J. 1976 Dec 4;2(6048):1351–1354. [PMC free article] [PubMed]
  • Clemens TL, Hendy GN, Graham RF, Baggiolini EG, Uskokovic MR, O'Riordan JL. A radioimmunoassay for 1,25-dihydroxycholecalciferol. Clin Sci Mol Med. 1978 Mar;54(3):329–332. [PubMed]
  • Moss DW, Whitby LG. A simplified heat-inactivation method for investigating alkaline phosphatase isoenzymes in serum. Clin Chim Acta. 1975 May 15;61(1):63–71. [PubMed]
  • Whitby LG, Moss DW. Analysis of heat inactivation curves of alkaline phosphatase isoenzymes in serum. Clin Chim Acta. 1975 Mar 24;59(3):361–367. [PubMed]
  • Whitaker KB, Whitby LG, Moss DW. Activities of bone and liver alkaline phosphatases in serum in health and disease. Clin Chim Acta. 1977 Oct 1;80(1):209–220. [PubMed]
  • McCarthy DM, Hibbin JA, Goldman JM. A role for 1,25-dihydroxyvitamin D3 in control of bone-marrow collagen deposition? Lancet. 1984 Jan 14;1(8368):78–80. [PubMed]
  • Grenville-Mathers R, Clark JB. The development of tuberculosis in Afro-Asian immigrants. Tubercle. 1979 Mar;60(1):25–29. [PubMed]
  • Bowry S, Chan CH, Weiss H, Katz S, Zimmerman HJ. Hepatic involvement in pulmonary tuberculosis. Histologic and functional characteristics. Am Rev Respir Dis. 1970 Jun;101(6):941–948. [PubMed]
  • Sen PK, Saha JR, Chatterjee R, Dutta TK. Liver function tests in health and tuberculosis. Indian J Med Res. 1972 May;60(5):674–682. [PubMed]
  • Prasad M, Tyagi SP, Ahmad KN, Bahadur P, Tajuddin M. Liver in pulmonary tuberculosis. Indian J Chest Dis. 1973 Jan;15(1):38–44. [PubMed]
  • Jha VK, Kotilingam K, Shukla PK, Roy DC, Joshi M. Liver function in pulmonary tuberculosis. Indian J Chest Dis. 1974 Jul;16(3):171–181. [PubMed]
  • Brodie MJ, Boobis AR, Dollery CT, Hillyard CJ, Brown DJ, MacIntyre I, Park BK. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther. 1980 Jun;27(6):810–814. [PubMed]

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