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Thorax. Nov 1984; 39(11): 844–849.
PMCID: PMC459935

Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers.

Abstract

The goblet cell and Clara cell populations of human distal airway epithelium were examined. The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly (p less than 0.001) greater number of goblet cells were found in the bronchioles of smokers compared than in those of non-smokers but no such difference was evident in terminal/respiratory bronchioles. Clara cell numbers in contrast were lower in the bronchioles (p less than 0.01) and terminal and respiratory bronchioles of smokers (p less than 0.01). Both of these alterations in cell frequency may adversely affect small airway function in smokers.

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Selected References

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  • Jeffery PK, Reid L. New observations of rat airway epithelium: a quantitative and electron microscopic study. J Anat. 1975 Nov;120(Pt 2):295–320. [PMC free article] [PubMed]
  • Ebert RV, Terracio MJ. The bronchiolar epithelium in cigarette smokers. Observations with the scanning electron microscope. Am Rev Respir Dis. 1975 Jan;111(1):4–11. [PubMed]
  • Stephens RJ, Freeman G, Crane SC, Furiosi NJ. Ultrastructural changes in the terminal bronchiole of the rat during continuous, low-level exposure to nitrogen dioxide. Exp Mol Pathol. 1971 Feb;14(1):1–19. [PubMed]
  • Stephens RJ, Freeman G, Evans MJ. Early response of lungs to low levels of nitrogen dioxide. Light and electron microscopy. Arch Environ Health. 1972 Mar;24(3):160–179. [PubMed]
  • Lamb D, Reid L. Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke. Br Med J. 1969 Jan 4;1(5635):33–35. [PMC free article] [PubMed]
  • Widdicombe JG, Pack RJ. The Clara cell. Eur J Respir Dis. 1982 May;63(3):202–220. [PubMed]
  • Niden AH. Bronchiolar and large alveolar cell in pulmonary phospholipid metabolism. Science. 1967 Dec 8;158(3806):1323–1324. [PubMed]
  • Cutz E, Conen PE. Ultrastructure and cytochemistry of Clara cells. Am J Pathol. 1971 Jan;62(1):127–141. [PMC free article] [PubMed]
  • Evans MJ, Cabral-Anderson LJ, Freeman G. Role of the Clara cell in renewal of the bronchiolar epithelium. Lab Invest. 1978 Jun;38(6):648–653. [PubMed]
  • Lamb D, Lumsden A. Intra-epithelial mast cells in human airway epithelium: evidence for smoking-induced changes in their frequency. Thorax. 1982 May;37(5):334–342. [PMC free article] [PubMed]
  • Jones R, Bolduc P, Reid L. Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: the effect of tobacco smoke with or without the anti-inflammatory agent phenylmethyloxadiazole. Br J Exp Pathol. 1973 Apr;54(2):229–239. [PMC free article] [PubMed]
  • Thurlbeck WM, Malaka D, Murphy K. Goblet cells in the peripheral airways in chronic bronchitis. Am Rev Respir Dis. 1975 Jul;112(1):65–69. [PubMed]
  • FREEMAN G, HAYDON GB. EMPHYSEMA AFTER LOW-LEVEL EXPOSURE TO NO2. Arch Environ Health. 1964 Jan;8:125–128. [PubMed]
  • Sturgess J, Reid L. The effect of isoprenaline and pilocarpine on (a) bronchial mucus-secreting tissue and (b) pancreas, salivary glands, heart, thymus, liver and spleen. Br J Exp Pathol. 1973 Aug;54(4):388–403. [PMC free article] [PubMed]
  • Jones R, Bolduc P, Reid L. Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: the effect of tobacco smoke with or without the anti-inflammatory agent phenylmethyloxadiazole. Br J Exp Pathol. 1973 Apr;54(2):229–239. [PMC free article] [PubMed]
  • Wright JL, Lawson LM, Pare PD, Wiggs BJ, Kennedy S, Hogg JC. Morphology of peripheral airways in current smokers and ex-smokers. Am Rev Respir Dis. 1983 Apr;127(4):474–477. [PubMed]
  • AUERBACH O, STOUT AP, HAMMOND EC, GARFINKEL L. Changes in bronchial epithelium in relation to sex, age, residence, smoking and pneumonia. N Engl J Med. 1962 Jul 19;267:111–119. [PubMed]
  • Sobonya RE, Kleinerman J. Morphometric studies of bronchi in young smokers. Am Rev Respir Dis. 1972 May;105(5):768–775. [PubMed]
  • Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med. 1974 Oct 10;291(15):755–758. [PubMed]
  • Azzopardi A, Thurlbeck WM. The histochemistry of the nonciliated bronchiolar epithelial cell. Am Rev Respir Dis. 1969 Apr;99(4):516–525. [PubMed]
  • Petrik P, Collet AJ. Quantitative electron microscopic autoradiography of in vivo incorporation of 3H-choline, 3H-leucine, 3H-acetate and 3H-galactose in non-ciliated bronchiolar (Clara) cells of mice. Am J Anat. 1974 Apr;139(4):519–533. [PubMed]
  • Smith P, Heath D, Moosavi H. The Clara cell. Thorax. 1974 Mar;29(2):147–163. [PMC free article] [PubMed]
  • Kuhn C, 3rd, Callaway LA, Askin FB. The formation of granules in the bronchiolar Clara cells of the rat. 1. Electron microscopy,. J Ultrastruct Res. 1974 Dec;49(3):387–400. [PubMed]
  • McDowell EM, Barrett LA, Glavin F, Harris CC, Trump BF. The respiratory epithelium. I. Human bronchus. J Natl Cancer Inst. 1978 Aug;61(2):539–549. [PubMed]

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