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Antimicrob Agents Chemother. 1974 October; 6(4): 501–506. | PMCID: PMC444679 |
Use of Available Dosage Forms of Cephalexin in Clinical Comparison with Phenoxymethyl Penicillin and Benzathine Penicillin in the Treatment of Streptococcal Pharyngitis in Children John M. Matsen,1 Ordean Torstenson,2 Stuart E. Siegel,3 and Hadassah Bacaner Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455 Department of Pediatrics, and Microbiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455 Department of Microbiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455 Abstract The effectiveness of cephalexin, an oral cephalosporin using a dosage equivalent to available capsular dosage forms, was studied in relation to the effectiveness of phenoxymethyl penicillin and benzathine penicillin in the treatment of 128 patients with beta-hemolytic streptococcal pharyngitis, all but six of whom had group A streptococci isolated from throat cultures. Approximately one-half, 66 patients, received cephalexin for 10 days; 34 patients received phenoxymethyl penicillin for 10 days; and 28 patients had a single injection of benzathine penicillin. There were four treatment failures determined bacteriologically post-therapy, two in the cephalexin treatment group and one each in the oral penicillin and intramuscular penicillin groups. Similar cure rates of 96.7, 97.1, and 96.4% were computed for the respective treatment regimens. Whereas intramuscular benzathine penicillin remains the regimen of choice in most instances, cephalexin appeared to be as effective as oral penicillin in the elimination of group A streptococci from the pharynx when oral treatment was desired for streptococcal pharyngitis. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (940K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Azimi PH, Cramblett HG, Del rosario AJ, Kronfol H, Haynes RE, Hilty MD. Cephalexin: treatment of streptococcal pharyngitis. J Pediatr. 1972 Jun;80(6):1042–1045. [PubMed]
- Disney FA, Breese BB, Green JL, Talpey WB, Tobin JR. Cephalexin and penicillin therapy of childhood beta-hemolytic streptococcal infections. Postgrad Med J. 1971 Feb;47(Suppl):47–51. [PubMed]
- Edwards EA. Protocol for micro antistreptolysin O determinations. J Bacteriol. 1964 May;87(5):1254–1255. [PubMed]
- Gau DW, Horn RF, Solomon RM, Johnson P, Leigh DA. Streptococcal tonsillitis in general practice. A comparison of cephalexin and penicillin therapy. Practitioner. 1972 Feb;208(244):276–281. [PubMed]
- Kaplan EL, Top FH, Jr, Dudding BA, Wannamaker LW. Diagnosis of streptococcal pharyngitis: differentiation of active infection from the carrier state in the symptomatic child. J Infect Dis. 1971 May;123(5):490–501. [PubMed]
- Kaplan EL, Anthony BF, Chapman SS, Ayoub EM, Wannamaker LW. The influence of the site of infection on the immune response to group A streptococci. J Clin Invest. 1970 Jul;49(7):1405–1414. [PubMed]
- Klein GC, Baker CN, Jones WL. "Upper limits of normal" antistreptolysin O and antideoxyribonuclease B titers. Appl Microbiol. 1971 Jun;21(6):999–1001. [PubMed]
- Matsen JM. Cephaloglycin in pediatric patients. Am J Dis Child. 1971 Jan;121(1):38–42. [PubMed]
- MAXTED WR. The use of bacitracin for identifying group A haemolytic streptococci. J Clin Pathol. 1953 Aug;6(3):224–226. [PubMed]
- MOODY MD, PADULA J, LIZANA D, HALL CT. EPIDEMIOLOGIC CHARACTERIZATION OF GROUP A STREPTOCOCCI BY T-AGGLUTINATION AND M-PRECIPITATION TESTS IN THE PUBLIC HEALTH LABORATORY. Health Lab Sci. 1965 Jul;2:149–162. [PubMed]
- Perkins RL, Carlisle HN, Saslaw S. Cephalexin: in vitro bacterial susceptibility, absorption in volunteers, and antibacterial activity of sera and urine. Am J Med Sci. 1968 Aug;256(2):122–129. [PubMed]
- Shapera RM, Hable KA, Matsen JM. Erythromycin therapy twice daily for streptococcal pharyngitis. Controlled comparison with erythromycin or penicillin phenoxymethyl four times daily or penicillin G benzathine. JAMA. 1973 Oct 29;226(5):531–535. [PubMed]
- Stillerman M, Isenberg HD, Moody M. Streptococcal pharyngitis therapy. Comparison of cephalexin, phenoxymethyl penicillin, and ampicillin. Am J Dis Child. 1972 May;123(5):457–461. [PubMed]
- Thornhill TS, Levison ME, Johnson WD, Kaye D. In vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin C antibiotic. Appl Microbiol. 1969 Mar;17(3):457–461. [PubMed]
- Wick WE. Cephalexin, a new orally absorbed cephalosporin antibiotic. Appl Microbiol. 1967 Jul;15(4):765–769. [PubMed]
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