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Journal List > Antimicrob Agents Chemother > v.6(2); Aug 1974

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Antimicrob Agents Chemother. 1974 August; 6(2): 183–190.
PMCID: PMC444625
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Characteristics and Expression of Tetracycline Resistance in Gram-Negative Bacteria Carrying the Pseudomonas R Factor RP1
Patricia L. Shipley and Ronald H. Olsen
1The University of Michigan, Department of Microbiology, The Medical School, Ann Arbor, Michigan 48104
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Abstract
The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycline accumulation by RP1-containing organisms. The tetracycline resistance mechanism is inactivated at low temperatures. The effect of metabolic inhibitors on tetracycline accumulation by susceptible organisms under various conditions indicates a possible nonspecific effect of cellular energy metabolism on tetracycline uptake.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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