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J Clin Invest. Aug 1959; 38(8): 1298–1315.
PMCID: PMC442084

STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

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Selected References

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  • GUTMAN AB. Some recent advances in the study of uric acid metabolism and gout. Bull N Y Acad Med. 1951 Mar;27(3):144–164. [PMC free article] [PubMed]
  • GUTMAN AB, YU TF. Gout, a derangement of purine metabolism. Adv Intern Med. 1952;5:227–302. [PubMed]
  • CRONE C, LASSEN UV. The effect of salicylic acid and acetylsalicylic acid on uric acid excretion and plasma uric acid concentration in the normal human subject. Acta Pharmacol Toxicol (Copenh) 1955;11(4):355–361. [PubMed]
  • YU TF, GUTMAN AB. Paradoxical retention of uric acid by uricosuric drugs in low dosage. Proc Soc Exp Biol Med. 1955 Nov;90(2):542–547. [PubMed]
  • New York Rheumatism Association. Ann Rheum Dis. 1955 Dec;14(4):444–445. [PMC free article]
  • GUTMAN AB, YU TF. Benemid (p-di-n-propylsulfamyl)-benzoic acid) as uricosuric agent in chronic gouty arthritis. Trans Assoc Am Physicians. 1951;64:279–288. [PubMed]
  • PASCALE LR, DUBIN A, HOFFMAN WS. Therapeutic value of probenecid (benemid) in gout. J Am Med Assoc. 1952 Jul 26;149(13):1188–1194. [PubMed]
  • GUTMAN A, YU TF, SIROTA JH. A study, by simultaneous clearance techniques, of salicylate excretion in man: effect of alkalinization of the urine by bicarbonate administration; effect of probenecid. J Clin Invest. 1955 May;34(5):711–721. [PMC free article] [PubMed]
  • GOLDTHWAIT JC, BUTLER CF, STILLMAN JS. The diagnosis of gout; significance of an elevated serum uric acid value. N Engl J Med. 1958 Dec 4;259(23):1095–1099. [PubMed]
  • SCHACHTER D, MANIS JG. Salicylate and salicyl conjugates: fluorimetric estimation, biosynthesis and renal excretion in man. J Clin Invest. 1958 Jun;37(6):800–807. [PMC free article] [PubMed]
  • HOFFMAN WS, NOBE C. The influence of urinary pH on the renal excretion of salicyl derivatives during aspirin therapy. J Lab Clin Med. 1950 Feb;35(2):237–248. [PubMed]
  • MACPHERSON CR, MILNE MD, EVANS BM. The excretion of salicylate. Br J Pharmacol Chemother. 1955 Dec;10(4):484–489. [PMC free article] [PubMed]
  • BERLINER RW. The kidney. Annu Rev Physiol. 1954;16:269–304. [PubMed]
  • MILNE MD, SCRIBNER BH, CRAWFORD MA. Non-ionic diffusion and the excretion of weak acids and bases. Am J Med. 1958 May;24(5):709–729. [PubMed]
  • Smith HW, Finkelstein N, Aliminosa L, Crawford B, Graber M. THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN. J Clin Invest. 1945 May;24(3):388–404. [PMC free article] [PubMed]
  • SALTERI F, CIRLA E, FASOLI A. Electromigration on filter paper of uric acid from serum and synovial fluid. Science. 1958 Jan 10;127(3289):85–86. [PubMed]
  • BERLINER RW, HILTON JG, YU TF, KENNEDY TJ. The renal mechanism for urate excretion in man. J Clin Invest. 1950 Apr;29(4):396–401. [PMC free article] [PubMed]
  • GUTMAN AB, YU TF. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med. 1957 Oct;23(4):600–622. [PubMed]
  • GUTMAN AB, YU TF. Renal regulation of uric acid excretion in normal and gouty man; modification by uricosuric agents. Bull N Y Acad Med. 1958 May;34(5):287–296. [PMC free article] [PubMed]
  • LAMBIOTTE C, BLANCHARD J, GRAFF S, GRAFF A. Thiosulphate clearance in pregnancy. J Clin Invest. 1950 Sep;29(9):1207–1213. [PMC free article] [PubMed]
  • SIROTA JH, YU TF, GUTMAN AB. Effect of benemid (p-[di-n-propylsulfamyl]-benzoic acid) on urate clearance and other discrete renal functions in gouty subjects. J Clin Invest. 1952 Jul;31(7):692–701. [PMC free article] [PubMed]
  • YU TF, SIROTA JH, GUTMAN AB. Effect of phenylbutazone (3,5 dioxo-1,2-diphenyl-4-n-butylpyrazolidine) on renal clearance of urate and other discrete renal functions in gouty subjects. J Clin Invest. 1953 Nov;32(11):1121–1132. [PMC free article] [PubMed]
  • YU TF, PATON BC, CHENKIN T, BURNS JJ, BRODIE BB, GUTMAN AB. Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent. J Clin Invest. 1956 Apr;35(4):374–385. [PMC free article] [PubMed]
  • BURNS JJ, YU TF, RITTERBAND A, PEREL JM, GUTMAN AB, BRODIE BB. A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671. J Pharmacol Exp Ther. 1957 Mar;119(3):418–426. [PubMed]
  • BURNS JJ, YU TF, BERGER L, GUTMAN AB. Zoxazolamine: physiological disposition, uricosuric properties. Am J Med. 1958 Sep;25(3):401–408. [PubMed]
  • YU TF, BERGER L, STONE DJ, WOLF J, GUTMAN AB. Effect of pyrazinamide and pyrazinoic acid on urate clearance and other discrete renal functions. Proc Soc Exp Biol Med. 1957 Oct;96(1):264–267. [PubMed]
  • YU TF, SIROTA JH, BERGER L, HALPERN M, GUTMAN AB. Effect of sodium lactate infusion on urate clearance in man. Proc Soc Exp Biol Med. 1957 Dec;96(3):809–813. [PubMed]
  • OGRYZLO MA, HARRISON J. Evaluation of uricosuric agents in chronic gout. Ann Rheum Dis. 1957 Dec;16(4):425–437. [PMC free article] [PubMed]
  • KERSLEY GD, COOK ER, TOVEY DC. Value of uricosuric agents and in particular of G. 28 315 in gout. Ann Rheum Dis. 1958 Sep;17(3):326–333. [PMC free article] [PubMed]
  • BOGER WP, STRICKLAND SC, BAYNE GM, GYLFE J. Probenecid and salicylates: the question of interaction in terms of penicillin excretion. J Lab Clin Med. 1955 Mar;45(3):478–484. [PubMed]
  • MARSON FG. Sodium salicylate and probenecid in the treatment of chronic gout; assessment of their relative effects in lowering serum uric acid levels. Ann Rheum Dis. 1954 Sep;13(3):233–245. [PMC free article] [PubMed]
  • PASCALE LR, DUBIN A, BRONSKY D, HOFFMAN WS. Inhibition of the uricosuric action of benemid by salicylate. J Lab Clin Med. 1955 May;45(5):771–777. [PubMed]
  • YU TF, BURNS JJ, GUTMAN AB. Results of a clinical trial of G-28315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects. Arthritis Rheum. 1958 Dec;1(6):532–543. [PubMed]

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