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Proc Natl Acad Sci U S A. Oct 1976; 73(10): 3651–3655.
PMCID: PMC431176

A mutant of Saccharomyces cerevisiae defective for nuclear fusion.


A mutant unable to fuse nuclei during mating has been isolated from standard wild-type Saccharomyces cerevisiae. Tetrad analysis of the mutation responsible for this defect (kar1-1) shows that it segregates as a single Mendelian factor. The defect kn kaf1-1 appears to be nuclear limited. Cytological and genetic evidence shows that in this mutant the events associated with zygote formation are normal until the point of nuclear fusion. The consequence of this defect is the formation of a multinucleate zygote which in subsequent divisions can segregate heterokaryons and haploid heterplasmons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences


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