• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. Sep 1976; 73(9): 3253–3257.
PMCID: PMC430996

Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.

Abstract

A new temperature-sensitive paralytic mutant of Drosophila, comatose, is compared behaviorally and physiologically with the previously known types, para and shi. All three have different properties with respect to kinetics of paralysis at high temperature and recovery from paralysis; com is hypersensitive to paralysis by cooling. Neurophysiological experimeents indicate different mechanisms for paralysis in each of the mutants.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (957K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Suzuki DT, Grigliatti T, Williamson R. Temperature-sensitive mutations in Drosophila melanogaster. VII. A mutation (para-ts) causing reversible adult paralysis. Proc Natl Acad Sci U S A. 1971 May;68(5):890–893. [PMC free article] [PubMed]
  • Grigliatti TA, Hall L, Rosenbluth R, Suzuki DT. Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults. Mol Gen Genet. 1973 Jan 24;120(2):107–114. [PubMed]
  • Benzer S. BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1112–1119. [PMC free article] [PubMed]
  • Ikeda K, Kaplan WD. Patterned neural activity of a mutant Drosophila melanogaster. Proc Natl Acad Sci U S A. 1970 Jul;66(3):765–772. [PMC free article] [PubMed]
  • Williamson R, Kaplan WD, Dagan D. A fly's leap from paralysis. Nature. 1974 Nov 15;252(5480):224–226. [PubMed]
  • HODGKIN AL, KATZ B. The effect of temperature on the electrical activity of the giant axon of the squid. J Physiol. 1949 Aug;109(1-2):240–249. [PMC free article] [PubMed]
  • Katz B, Miledi R. The effect of temperature on the synaptic delay at the neuromuscular junction. J Physiol. 1965 Dec;181(3):656–670. [PMC free article] [PubMed]
  • Ikeda K, Ozawa S, Hagiwara S. Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster. Nature. 1976 Feb 12;259(5543):489–491. [PubMed]
  • Kelly LE, Suzuki DT. The effects of increased temperature on electroretinograms of temperature-sensitive paralysis mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4906–4909. [PMC free article] [PubMed]
  • MCCANN FV, BOETTIGER EG. Studies on the flight mechanism of insects. I. The electrophysiology of fibrillar flight muscle. J Gen Physiol. 1961 Sep;45:125–142. [PMC free article] [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...