• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. Mar 1978; 19(3): 919–922.
PMCID: PMC422279

Platelet aggregation in rabbits made tolerant to endotoxin.

Abstract

Endotoxin may cause abnormal deposition of platelet-endotoxin aggregates, and this event could have damaging effects. We compared the aggregation characteristics of platelets from rabbits made tolerant to the lethal effects of endotoxin with those of platelets from normal rabbits. Platelets from tolerant rabbits aggregated more rapidly (greater than 90 s faster) in the presence of endotoxin than did platelets from nontolerant animals. Furthermore, platelets from tolerant animals aggregated reversibly. These characteristics of platelets from tolerant animals are due to humoral factors in the plasma, because 1:1 dilution of normal platelet-rich plasma with plasma from tolerant rabbits caused the normal platelets to behave like those from tolerant animals. Survival after challenge with lethal quantities of endotoxin was enhanced in tolerant rabbits; this may be due to promotion of more efficient removal of endotoxin-platelet complexes from the blood by the reticuloendothelial system.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (579K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CAREY FJ, BRAUDE AI, ZALESKY M. Studies with radioactive endotoxin. III. The effect of tolerance on the distribution of radioactivity after intravenous injection of Escherichia coli endotoxin labeled with Cr51. J Clin Invest. 1958 Mar;37(3):441–457. [PMC free article] [PubMed]
  • CLUFF LE. Studies of the effect bacterial endotoxins on rabbit leucocytes. II. Development of acquired resistance. J Exp Med. 1953 Oct;98(4):349–364. [PMC free article] [PubMed]
  • Das J, Schwartz AA, Folkman J. Clearance of endotoxin by platelets: role in increasing the accuracy of the Limulus gelation test and in combating experimental endotoxemia. Surgery. 1973 Aug;74(2):235–240. [PubMed]
  • Donal KJ. The role of platelets in the clearance of colloidal carbon from blood in rabbits: a light and electron microscope study. Pathology. 1972 Oct;4(4):295–301. [PubMed]
  • Evans G, Lewis AF, Mustard JF. The role of platelet aggregation in the development of endotoxin shock. Br J Surg. 1969 Aug;56(8):624–624. [PubMed]
  • Goldstein IM, Wünschmann B, Astrup T, Henderson ES. Effects of bacterial endotoxin on the fibrinolytic activity of normal human leukocytes. Blood. 1971 Apr;37(4):447–453. [PubMed]
  • Greisman SE, Hornick RB. The nature of endotoxin tolerance. Trans Am Clin Climatol Assoc. 1975;86:43–50. [PMC free article] [PubMed]
  • HERION JC, WALKER RI, HERRING WB, PALMER JG. EFFECTS OF ENDOTOXIN AND NITROGEN MUSTARD ON LEUKOCYTE KINETICS. Blood. 1965 Apr;25:522–540. [PubMed]
  • HERRING WB, HERION JC, WALKER RI, PALMER JG. Distribution and clearance of circulating endotoxin. J Clin Invest. 1963 Jan;42:79–87. [PMC free article] [PubMed]
  • Howes EL, Jr, McKay DG, Margaretten W. The participation of the platelet in the vascular response to endotoxemia in the rabbit eye. Am J Pathol. 1973 Jan;70(1):25–44. [PMC free article] [PubMed]
  • Marder RJ, Fiedel BA, Osmand AP, Gewurz H. Inhibition of rabbit platelet aggregation and clot retraction by rabbit and human c-reactive proteins. Proc Soc Exp Biol Med. 1977 May;155(1):44–47. [PubMed]
  • Moncada S, Gryglewski RJ, Bunting S, Vane JR. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins. 1976 Nov;12(5):715–737. [PubMed]
  • NOYES HE, McINTURF CR, BLAHUTA GJ. Studies on distribution of Escherichia coli endotoxin in mice. Proc Soc Exp Biol Med. 1959 Jan;100(1):65–68. [PubMed]
  • Quesenberry P, Halperin J, Ryan M, Stohlman F., Jr Tolerance to the granulocyte-releasing and colony-stimulating factor elevating effects of endotoxin. Blood. 1975 Jun;45(6):789–800. [PubMed]
  • Van Aken WG, Vreeken J. Accumulaon of macromolecular particles in the reticuloendothelial system (RES) mediated by platelet aggregation and disaggregation. Thromb Diath Haemorrh. 1969 Dec 31;22(3):496–507. [PubMed]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...