• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. Jan 1977; 15(1): 337–339.
PMCID: PMC421369

Protection against endotoxin-induced mortality in mice treated with transition metal salts.

Abstract

Administration of manganese or chromium chloride 1 h before challenge with a single bolus of Salmonella typhosa endotoxin completely obviated death in endotoxin-challenged mice.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (455K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Balis JU, Gerber LI, Rappaport ES, Neville WE. Mechanisms of blood-vascular reactions of the primate lung to acute endotoxemia. Exp Mol Pathol. 1974 Aug;21(1):123–137. [PubMed]
  • Cline MJ, Melmon KL, Davis WC, Williams HE. Mechanism of endotoxin interaction with human leucocytes. Br J Haematol. 1968 Dec;15(6):539–547. [PubMed]
  • English D, Andersen BR. Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods. 1974 Aug;5(3):249–252. [PubMed]
  • Fantin GP, Bottecchia D. Effect of manganese on the ADP-induced platelet aggregation. Experientia. 1974 May 15;30(5):555–556. [PubMed]
  • Filkins JP. Hepatic lysosomes and the inactivation of endotoxin. J Reticuloendothel Soc. 1971 May;9(5):480–490. [PubMed]
  • GELLER P, MERRILL ER, JAWETZ E. Effects of cortisone and antibiotics on lethal action of endotoxins in mice. Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):716–719. [PubMed]
  • Goldstein IM, Wünschmann B, Astrup T, Henderson ES. Effects of bacterial endotoxin on the fibrinolytic activity of normal human leukocytes. Blood. 1971 Apr;37(4):447–453. [PubMed]
  • JANOFF A, WEISSMANN G, ZWEIOFACH BW, THOMAS L. Pathogenesis of experimental shock. IV. Studies on lysosomes in normal and tolerant animals subjected to lethal trauma and endotoxemia. J Exp Med. 1962 Oct 1;116:451–466. [PMC free article] [PubMed]
  • Jansön PM, Kühn SH, Geldenhuys JJ. Lysosomal disruption during the development of endotoxic shock in the baboon. S Afr Med J. 1975 Jun 21;49(26):1041–1047. [PubMed]
  • Latour JG, Leger C. Prevention by glucocorticoids of disseminated intravascular coagulation induced by endotoxin: mechanisms. J Lab Clin Med. 1975 Jun;85(6):934–949. [PubMed]
  • Phillips LL, Margaretten W, McKay DG. Changes in the fibrinolytic enzyme system following intravascular coagulation induced by thrombin and endotoxin. Am J Obstet Gynecol. 1968 Feb 1;100(3):319–326. [PubMed]
  • Prigal SJ, Herp A, Gerstein J. The detoxification of lipopolysaccharides derived from bacterial endotoxins by ferric chloride. J Reticuloendothel Soc. 1973 Sep;14(3):250–257. [PubMed]
  • Snyder SL, Walker RI. Inhibition of lethality in endotoxin-challenged mice treated with zinc chloride. Infect Immun. 1976 Mar;13(3):998–1000. [PMC free article] [PubMed]
  • Waters MD, Gardner DE, Aranyi C, Coffin DL. Metal toxicity for rabbit alveolar macrophages in vitro. Environ Res. 1975 Feb;9(1):32–47. [PubMed]
  • Ward PA, Goldschmidt P, Greene ND. Suppressive effects of metal salts on leukocyte and fibroblastic function. J Reticuloendothel Soc. 1975 Nov;18(5):313–321. [PubMed]
  • WEISSMANN G, THOMAS L. Studies on lysosomes. I. The effects of endotoxin, endotoxin tolerance, and cortisone on the release of acid hydrolases from a granular fraction of rabbit liver. J Exp Med. 1962 Oct 1;116:433–450. [PMC free article] [PubMed]
  • Weissmann G, Zurier RB, Spieler PJ, Goldstein IM. Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J Exp Med. 1971 Sep 1;134(3 Pt 2):149s–165s. [PubMed]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...