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Infect Immun. Dec 1977; 18(3): 775–779.
PMCID: PMC421302

Vero response to a cytotoxin of Escherichia coli.


A cytotoxin was found in culture filtrates of a number of Escherichia coli strains that differed from the known heat-stable and heat-labile enterotoxins of E. coli. It was cytotoxic for Vero but not for Y-1 or CHO cells, and its effect on Vero was distinctly different from that of heat-labile enterotoxin. It was labile to heat and antigenically different from heat-labile enterotoxin, and membrane filtration indicated a molecular weight of 10,000 to 30,000.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dean AG, Ching YC, Williams RG, Harden LB. Test for Escherichia coli enterotoxin using infant mice: application in a study of diarrhea in children in Honolulu. J Infect Dis. 1972 Apr;125(4):407–411. [PubMed]
  • Kasai GJ, Burrows W. The titration of cholera toxin and antitoxin in the rabbit ileal loop. J Infect Dis. 1966 Dec;116(5):606–614. [PubMed]
  • Keusch GT, Donta ST. Classification of enterotoxins on the basis of activity in cell culture. J Infect Dis. 1975 Jan;131(1):58–63. [PubMed]
  • Sack RB, Sack DA, Mehlman IJ, Orskov F, Orskov I. Enterotoxigenic Escherichia coli isolated from food. J Infect Dis. 1977 Feb;135(2):313–317. [PubMed]
  • Speirs JI, Stavric S, Konowalchuk J. Assay of Escherichia coli heat-labile enterotoxin with vero cells. Infect Immun. 1977 May;16(2):617–622. [PMC free article] [PubMed]
  • Stavric S, Jeffrey D. A modified bioassay for heat-stable Escherichia coli enterotoxin1. Can J Microbiol. 1977 Mar;23(3):331–336. [PubMed]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)


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