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Infect Immun. Sep 1975; 12(3): 550–555.
PMCID: PMC415322

Comparison of leukocyte count and function in smoking and nonsmoking young men.


Leukocyte function and other hematological measurements were tested in 14 smoking and 13 nonsmoking young men free of intercurrent or chronic diseases. Leukocyte chemotaxis was depressed in smoking subjects when compared to the same subjects abstaining from cigarettes or to the nonsmokers. Smoking did not affect the whole blood bactericidal capacity of leukocytes and serum for Staphyloccus aureus or Klebsiella pneumoniae. Total leukocyte counts, hematocritis, and monocyte counts were higher in the smoking subjects when compared to the nonsmokers.

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Selected References

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  • Baum J, Mowat AG, Kirk JA. A simplified method for the measurement of chemotaxis of polymorphonuclear leukocytes from human blood. J Lab Clin Med. 1971 Mar;77(3):501–509. [PubMed]
  • Berenberg JL, Ward PA. Chemotactic factor inactivator in normal human serum. J Clin Invest. 1973 May;52(5):1200–1206. [PMC free article] [PubMed]
  • Bourne HR, Lehrer RI, Cline MJ, Melmon KL. Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. J Clin Invest. 1971 Apr;50(4):920–929. [PMC free article] [PubMed]
  • BOYDEN S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962 Mar 1;115:453–466. [PMC free article] [PubMed]
  • Castro O, Andriole VT, Finch SC. Whole blood phagocytic and bactericidal activity for Staphylococcus aureus. J Lab Clin Med. 1972 Dec;80(6):857–870. [PubMed]
  • Clark RA, Kimball HR. Defective granulocyte chemotaxis in the Chediak-Higashi syndrome. J Clin Invest. 1971 Dec;50(12):2645–2652. [PMC free article] [PubMed]
  • Cohen AB, Cline MJ. The human alveolar macrophage: isolation, cultivation in vitro, and studies of morphologic and functional characteristics. J Clin Invest. 1971 Jul;50(7):1390–1398. [PMC free article] [PubMed]
  • Corre F, Lellouch J, Schwartz D. Smoking and leucocyte-counts. Results of an epidemiological survey. Lancet. 1971 Sep 18;2(7725):632–634. [PubMed]
  • Cox JP, Karnovsky ML. The depression of phagocytosis by exogenous cyclic nucleotides, prostaglandins, and theophylline. J Cell Biol. 1973 Nov;59(2 Pt 1):480–490. [PMC free article] [PubMed]
  • EISEN ME, HAMMOND EC. The effect of smoking on packed cell volume, red blood cell counts, haemoglobin and platelet counts. Can Med Assoc J. 1956 Sep 15;75(6):520–523. [PMC free article] [PubMed]
  • Finklea JF, Hasselblad V, Sandifer SH, Hammer DI, Lowrimore GR. Cigarette smoking and acute non-influenzal respiratory disease in military cadets. Am J Epidemiol. 1971 Jun;93(6):457–462. [PubMed]
  • Friedman GD, Siegelaub AB, Seltzer CC, Feldman R, Collen MF. Smoking habits and the leukocyte count. Arch Environ Health. 1973 Mar;26(3):137–143. [PubMed]
  • Green GM, Carolin D. The depressant effect of cigarette smoke on the in vitro antibacterial activity of alveolar macrophages. N Engl J Med. 1967 Feb 23;276(8):421–427. [PubMed]
  • Harris JO, Swenson EW, Johnson JE., 3rd Human alveolar macrophages: comparison of phagocytic ability, glucose utilization, and ultrastructure in smokers and nonsmokers. J Clin Invest. 1970 Nov;49(11):2086–2096. [PMC free article] [PubMed]
  • Isager H, Hagerup L. Relationship between cigarette smoking and high packed cell volume and haemoglobin levels. Scand J Haematol. 1971;8(4):241–244. [PubMed]
  • Jaanus SD, Rubin RP. Analysis of the role of cyclic adenosine 3',5'-monophosphate in catecholamine release. J Physiol. 1974 Mar;237(2):465–476. [PMC free article] [PubMed]
  • Johnson GS, Morgan WD, Pastan I. Regulation of cell motility by cyclic AMP. Nature. 1972 Jan 7;235(5332):54–56. [PubMed]
  • Kannel WB, Gordon T, Wolf PA, McNamara P. Hemoglobin and the risk of cerebral infarction: the Framingham Study. Stroke. 1972 Jul-Aug;3(4):409–420. [PubMed]
  • Okuno T. Smoking and blood changes. JAMA. 1973 Sep 10;225(11):1387–1388. [PubMed]
  • Parulkar VG, Barua MJ, Bhatt JV. Smoking and leucocyte counts. J Postgrad Med. 1973 Jul;19(3):132–135. [PubMed]
  • Pinkett MO, Cowdrey CR, Nowell PC. Mixed hematopoietic and pulmonary origin of 'alveolar macrophages' as demonstrated by chromosome markers. Am J Pathol. 1966 May;48(5):859–867. [PMC free article] [PubMed]
  • Sulek K, Jedrzejczak W. Wpływ palenia papierosów na liczbe i obraz krwinek białch. Wiad Lek. 1973 Apr 15;26(8):725–728. [PubMed]
  • Ward PA. Leukotactic factors in health and disease. Am J Pathol. 1971 Sep;64(3):521–530. [PMC free article] [PubMed]
  • Warr GA, Martin RR. Chemotactic responsiveness of human alveolar macrophages: effects of cigarette smoking. Infect Immun. 1974 Apr;9(4):769–771. [PMC free article] [PubMed]
  • WATTS DT. The effect of nicotine and smoking on the secretion of epinephrine. Ann N Y Acad Sci. 1960 Sep;90:74–80. [PubMed]
  • Zigmond SH, Hirsch JG. Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med. 1973 Feb 1;137(2):387–410. [PMC free article] [PubMed]

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