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Proc Natl Acad Sci U S A. Oct 1979; 76(10): 5269–5273.
PMCID: PMC413122

Mathematical model for studying genetic variation in terms of restriction endonucleases.

Abstract

A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed.

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Selected References

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