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EMBO J. Mar 1989; 8(3): 681–686.
PMCID: PMC400861

Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.

Abstract

Mannose 6-phosphate, insulin like growth factors I and II (IGF I, IGF II), insulin and epidermal growth factor (EGF) induce a 1.5- to 2-fold increase of mannose 6-phosphate binding sites at the cell surface of human skin fibroblasts. The increase is completed within 10-15 min, is dose and temperature dependent, reversible and transient even in the presence of the effectors. It is due to a redistribution of mannose 6-phosphate/IGF II receptors from internal membranes to the cell surface, while the affinity of the receptors is not affected. Combinations of mannose 6-phosphate with IGF I, IGF II or EGF stimulate the redistribution of the receptor to the cell surface in an additive manner, while combinations of the growth factors result in a non-additive stimulation of redistribution. The redistribution is not dependent on extracellular calcium and appears also to be independent of changes of free intracellular calcium. Pre-treatment of fibroblasts with cholera toxin or pertussis toxin increases the number of cell surface receptors 2- and 1.5-fold, respectively. Neither of the toxins affects the redistribution of mannose 6-phosphate/IGF II receptors induced by the growth factors, while both toxins abolish the receptor redistribution induced by mannose 6-phosphate. These results suggest a multiple regulation of the cell surface expression of mannose 6-phosphate/IGF II receptors by Gs- and Gi-like proteins sensitive to cholera toxin and pertussis toxin and by stimulation of mannose 6-phosphate/IGF II, IGF I and EGF receptors.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  • Corvera S, Folander K, Clairmont KB, Czech MP. A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7567–7571. [PMC free article] [PubMed]
  • Fischer HD, Gonzalez-Noriega A, Sly WS. Beta-glucuronidase binding to human fibroblast membrane receptors. J Biol Chem. 1980 Jun 10;255(11):5069–5074. [PubMed]
  • Gelfand EW, Mills GB, Cheung RK, Lee JW, Grinstein S. Transmembrane ion fluxes during activation of human T lymphocytes: role of Ca2+, Na+/H+ exchange and phospholipid turnover. Immunol Rev. 1987 Feb;95:59–87. [PubMed]
  • Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615–649. [PubMed]
  • Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985 Mar 25;260(6):3440–3450. [PubMed]
  • Hari J, Pierce SB, Morgan DO, Sara V, Smith MC, Roth RA. The receptor for insulin-like growth factor II mediates an insulin-like response. EMBO J. 1987 Nov;6(11):3367–3371. [PMC free article] [PubMed]
  • Kaplan A, Achord DT, Sly WS. Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts. Proc Natl Acad Sci U S A. 1977 May;74(5):2026–2030. [PMC free article] [PubMed]
  • Kiess W, Blickenstaff GD, Sklar MM, Thomas CL, Nissley SP, Sahagian GG. Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor. J Biol Chem. 1988 Jul 5;263(19):9339–9344. [PubMed]
  • LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed]
  • MacDonald RG, Pfeffer SR, Coussens L, Tepper MA, Brocklebank CM, Mole JE, Anderson JK, Chen E, Czech MP, Ullrich A. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science. 1988 Mar 4;239(4844):1134–1137. [PubMed]
  • Maly P, Lüthi C. Characterization of affinity-purified type I insulin-like growth factor receptor from human placenta. Biochem Biophys Res Commun. 1986 Aug 14;138(3):1257–1262. [PubMed]
  • Mellas J, Gavin JR, 3rd, Hammerman MR. Multiplication-stimulating activity-induced alkalinization of canine renal proximal tubular cells. J Biol Chem. 1986 Nov 5;261(31):14437–14442. [PubMed]
  • Morgan DO, Edman JC, Standring DN, Fried VA, Smith MC, Roth RA, Rutter WJ. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature. 1987 Sep 24;329(6137):301–307. [PubMed]
  • Neer EJ, Clapham DE. Roles of G protein subunits in transmembrane signalling. Nature. 1988 May 12;333(6169):129–134. [PubMed]
  • Neher E. The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum. J Physiol. 1988 Jan;395:193–214. [PMC free article] [PubMed]
  • Nishimoto I, Hata Y, Ogata E, Kojima I. Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein. J Biol Chem. 1987 Sep 5;262(25):12120–12126. [PubMed]
  • Oka Y, Czech MP. The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand. J Biol Chem. 1986 Jul 15;261(20):9090–9093. [PubMed]
  • Oka Y, Mottola C, Oppenheimer CL, Czech MP. Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4028–4032. [PMC free article] [PubMed]
  • Rechler MM, Nissley SP. The nature and regulation of the receptors for insulin-like growth factors. Annu Rev Physiol. 1985;47:425–442. [PubMed]
  • Rogers SA, Hammerman MR. Insulin-like growth factor II stimulates production of inositol trisphosphate in proximal tubular basolateral membranes from canine kidney. Proc Natl Acad Sci U S A. 1988 Jun;85(11):4037–4041. [PMC free article] [PubMed]
  • Roth RA. Structure of the receptor for insulin-like growth factor II: the puzzle amplified. Science. 1988 Mar 11;239(4845):1269–1271. [PubMed]
  • Roth RA, Stover C, Hari J, Morgan DO, Smith MC, Sara V, Fried VA. Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor. Biochem Biophys Res Commun. 1987 Dec 16;149(2):600–606. [PubMed]
  • Sessions CM, Emler CA, Schalch DS. Interaction of insulin-like growth factor II with rat chondrocytes: receptor binding, internalization, and degradation. Endocrinology. 1987 May;120(5):2108–2116. [PubMed]
  • Stein M, Zijderhand-Bleekemolen JE, Geuze H, Hasilik A, von Figura K. Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes. EMBO J. 1987 Sep;6(9):2677–2681. [PMC free article] [PubMed]
  • Tally M, Enberg G, Li CH, Hall K. The specificity of the human IGF-2 receptor. Biochem Biophys Res Commun. 1987 Sep 30;147(3):1206–1212. [PubMed]
  • Tally M, Li CH, Hall K. IGF-2 stimulated growth mediated by the somatomedin type 2 receptor. Biochem Biophys Res Commun. 1987 Oct 29;148(2):811–816. [PubMed]
  • Tong PY, Tollefsen SE, Kornfeld S. The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II. J Biol Chem. 1988 Feb 25;263(6):2585–2588. [PubMed]
  • von Figura K, Hasilik A. Lysosomal enzymes and their receptors. Annu Rev Biochem. 1986;55:167–193. [PubMed]
  • Waheed A, Braulke T, Junghans U, von Figura K. Mannose 6-phosphate/insulin like growth factor II receptor: the two types of ligands bind simultaneously to one receptor at different sites. Biochem Biophys Res Commun. 1988 May 16;152(3):1248–1254. [PubMed]
  • Wardzala LJ, Simpson IA, Rechler MM, Cushman SW. Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane. J Biol Chem. 1984 Jul 10;259(13):8378–8383. [PubMed]
  • Barenton B, Guyda HJ, Goodyer CG, Polychronakos C, Posner BI. Specificity of insulin-like growth factor binding to type-II IGF receptors in rabbit mammary gland and hypophysectomized rat liver. Biochem Biophys Res Commun. 1987 Dec 16;149(2):555–561. [PubMed]
  • Braulke T, Gartung C, Hasilik A, von Figura K. Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes? J Cell Biol. 1987 Jun;104(6):1735–1742. [PMC free article] [PubMed]
  • Bretthauer RK, Kaczorowski GJ, Weise MJ. Characterization of a phosphorylated pentasaccharide isolated from Hansenula holstii NRRL Y-2448 phosphomannan. Biochemistry. 1973 Mar 27;12(7):1251–1256. [PubMed]
  • Bryson JM, Baxter RC. High-affinity receptor for insulin-like growth factor II in rat liver: properties and regulation in vivo. J Endocrinol. 1987 Apr;113(1):27–35. [PubMed]
  • Corvera S, Roach PJ, DePaoli-Roach AA, Czech MP. Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II. J Biol Chem. 1988 Mar 5;263(7):3116–3122. [PubMed]

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