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EMBO J. Apr 18, 1995; 14(8): 1812–1818.
PMCID: PMC398274

Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides.


Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.

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Selected References

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