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Journal List > Proc Natl Acad Sci U S A > v.93(8); Apr 16, 1996

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Proc Natl Acad Sci U S A. 1996 April 16; 93(8): 3205–3208.
PMCID: PMC39583
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Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.
J Moskovitz, N A Jenkins, D J Gilbert, N G Copeland, F Jursky, H Weissbach, and N Brot
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110-1199, USA.
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Abstract
Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) is a ubiquitous protein that can reduce methionine sulfoxide residues in proteins as well as in a large number of methyl sulfoxide compounds. The expression of MsrA in various rat tissues was determined by using immunocytochemical staining. Although the protein was found in all tissues examined, it was specifically localized to renal medulla and retinal pigmented epithelial cells, and it was prominent in neurons and throughout the nervous system. In addition, blood and alveolar macrophages showed high expression of the enzyme. The msrA gene was mapped to the central region of mouse chromosome 14, in a region of homology with human chromosomes 13 and 8p21.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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