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Proc Natl Acad Sci U S A. Nov 1978; 75(11): 5618–5622.
PMCID: PMC393018

Model for evolution of Y chromosomes and dosage compensation.

Abstract

Some difficulties with the classical model for the evolution of a genetically invert Y chromosome are discussed. An alternative model is proposed, which is based on the principle of Mullers ratchet; this involves the accumulation of chromosomes bearing deleterious mutant genes in a finite population in the absence of crossing-over. This process would result in the gradual increase, with time, in the number of mutant loci carried in an average Y chromosome, although the frequency of individual deleterious alleles at most loci remains low. It is shown that this creates a selection pressure for differentially increasing the activity of the X chromosome in heterogametic individuals at the expense of that of the Y, leading eventually to a genetically inert Y chromosome and to the evolution of dosage compensation.

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Selected References

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  • Dronamraju KR. The function of the y-chromosome in man, animals, and plants. Adv Genet. 1965;13:227–310. [PubMed]
  • Muller HJ. Genetic Variability, Twin Hybrids and Constant Hybrids, in a Case of Balanced Lethal Factors. Genetics. 1918 Sep;3(5):422–499. [PMC free article] [PubMed]
  • Mukai T, Chigusa SI, Mettler LE, Crow JF. Mutation rate and dominance of genes affecting viability in Drosophila melanogaster. Genetics. 1972 Oct;72(2):335–355. [PMC free article] [PubMed]
  • Simmons MJ, Crow JF. Mutations affecting fitness in Drosophila populations. Annu Rev Genet. 1977;11:49–78. [PubMed]
  • Lyon MF. Mechanisms and evolutionary origins of variable X-chromosome activity in mammals. Proc R Soc Lond B Biol Sci. 1974 Nov 5;187(1088):243–268. [PubMed]
  • MULLER HJ. Our load of mutations. Am J Hum Genet. 1950 Jun;2(2):111–176. [PMC free article] [PubMed]
  • MULLER HJ. THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE. Mutat Res. 1964 May;106:2–9. [PubMed]
  • Felsenstein J. The evolutionary advantage of recombination. Genetics. 1974 Oct;78(2):737–756. [PMC free article] [PubMed]
  • Felsenstein J, Yokoyama S. The evolutionary advantage of recombination. II. Individual selection for recombination. Genetics. 1976 Aug;83(4):845–859. [PMC free article] [PubMed]
  • Mukherjee AS, Beermann W. Synthesis of ribonucleic acid by the X-chromosomes of Drosophila melanogaster and the problem of dosage compensation. Nature. 1965 Aug 14;207(998):785–786. [PubMed]
  • Lakhotia SC, Mukherjee AS. Chromosomal basis of dosage compensation in Drosophila. I. Cellular autonomy of hyperactivity of the male X-chromosome in salivary glands and sex differentiation. Genet Res. 1969 Oct;14(2):137–150. [PubMed]
  • Abraham I, Lucchesi JC. Dosage compensation of genes on the left and right arms of the X chromosome of Drosophila pseudoobscura and Drosophila willistoni. Genetics. 1974 Dec;78(4):1119–1126. [PMC free article] [PubMed]
  • Mukherjee AS, Chatterjee SN. Chromosomal basis of dosage compensation in Drosophila VIII. Faster replication and hyperactivity of both arms of the X-chromosome in males of Drosophila pseudoobscura and their possible significance. Chromosoma. 1975 Nov 24;53(2):91–105. [PubMed]
  • Strobel E, Pelling C, Arnheim N. Incomplete dosage compensation in an evolving Drosophila sex chromosome. Proc Natl Acad Sci U S A. 1978 Feb;75(2):931–935. [PMC free article] [PubMed]
  • Macknight RH. The Sex-Determining Mechanism of Drosophila Miranda. Genetics. 1939 Mar;24(2):180–201. [PMC free article] [PubMed]
  • Lucchesi JC. Dosage compensation in Drosophila. Annu Rev Genet. 1973;7:225–237. [PubMed]
  • Richardson BJ, Czuppon AB, Sharman GB. Inheritance of glucose-6-phosphate dehydrogenase variation in kangaroos. Nat New Biol. 1971 Mar 31;230(13):154–155. [PubMed]
  • Cooper DW, VandeBerg JL, Sharman GB, Poole WE. Phosphoglycerate kinase polymorphism in kangaroos provides further evidence for paternal X inactivation. Nat New Biol. 1971 Mar 31;230(13):155–157. [PubMed]
  • Cooper DW. Directed genetic change model for X chromosome inactivation in eutherian mammals. Nature. 1971 Apr 2;230(5292):292–294. [PubMed]
  • Brown SW, Chandra HS. Inactivation system of the mammalian X chromosome. Proc Natl Acad Sci U S A. 1973 Jan;70(1):195–199. [PMC free article] [PubMed]
  • Lifschytz E, Lindsley DL. The role of X-chromosome inactivation during spermatogenesis (Drosophila-allocycly-chromosome evolution-male sterility-dosage compensation). Proc Natl Acad Sci U S A. 1972 Jan;69(1):182–186. [PMC free article] [PubMed]
  • Stewart BR, Merriam JR. Regulation of gene activity by dosage compensation at the chromosomal level in drosophila. Genetics. 1975 Apr;79(4):635–647. [PMC free article] [PubMed]
  • Maroni G, Plaut W. Dosage Compensation in DROSOPHILA MELANOGASTER Triploids. II. Glucose-6-Phosphate Dehydrogenase Activity. Genetics. 1973 Jun;74(2):331–342. [PMC free article] [PubMed]
  • Schwartz D. The application of the maize-derived gene competition model to the problem of dosage compensation in Drosophila. Genetics. 1973 Dec;75(4):639–641. [PMC free article] [PubMed]
  • Hamilton WD. Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. Science. 1967 Apr 28;156(3774):477–488. [PubMed]

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