• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. May 1971; 68(5): 890–893.
PMCID: PMC389073

Temperature-Sensitive Mutations in Drosophila melanogaster, VII. A Mutation (parats) Causing Reversible Adult Paralysis

Abstract

A temperature-sensitive mutation, parats, in Drosophila melanogaster causes an immediate, but reversible, paralysis of adult flies when they are shifted from 22°C to 29°C. The mutation is a sex-linked recessive that maps 2.8 units to the left of f. Wild-type flies observed for 2-hr periods exhibited normal mobility at all temperatures between 22°C and 35°C. From 22°C to 25°C, parats flies were wild type in walking, climbing, and flying ability. At 1-degree intervals above 25°C, parats flies became increasingly debilitated; at 29°C, complete paralysis occurred. After flies were maintained for prolonged intervals at 29°C, some activity could be recovered at that temperature. Studies of the behavior of mosaics at 29°C revealed a requirement of the (+) allele in the head for mobility, and a thoracic component for proper leg movement. Normal electroretinograms were obtained at both 22°C and 30°C. The results suggest a temperature-sensitive defect in the nervous system.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (885K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Grigliatti T, Suzuki DT. Temperature-sensitive mutations in Drosophila melanogaster. V. A mutation affecting concentrations of pteridines. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1101–1108. [PMC free article] [PubMed]
  • Hotta Y, Benzer S. Abnormal electroretinograms in visual mutants of Drosophila. Nature. 1969 Apr 26;222(5191):354–356. [PubMed]
  • Hotta Y, Benzer S. Genetic dissection of the Drosophila nervous system by means of mosaics. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1156–1163. [PMC free article] [PubMed]
  • Ikeda K, Kaplan WD. Patterned neural activity of a mutant Drosophila melanogaster. Proc Natl Acad Sci U S A. 1970 Jul;66(3):765–772. [PMC free article] [PubMed]
  • Pak WL, Grossfield J, White NV. Nonphototactic mutants in a study of vision of Drosophila. Nature. 1969 Apr 26;222(5191):351–354. [PubMed]
  • Hinton CW. The Behavior of an Unstable Ring Chromosome of Drosophila Melanogaster. Genetics. 1955 Nov;40(6):951–961. [PMC free article] [PubMed]
  • Bryant PJ, Schneiderman HA. Cell lineage, growth, and determination in the imaginal leg discs of Drosophila melanogaster. Dev Biol. 1969 Sep;20(3):263–290. [PubMed]
  • Ikeda K, Kaplan WD. Unilaterally patterned neural activity of gynandromorphs, mosaic for a neurological mutant of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1480–1487. [PMC free article] [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...