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Proc Natl Acad Sci U S A. Aug 6, 1996; 93(16): 8479–8484.
PMCID: PMC38697

Class 3 Hox genes in insects and the origin of zen.

Abstract

We have cloned, from a beetle and a locust, genes that are homologous to the class 3 Hox genes of vertebrates. Outside the homeobox they share sequence motifs with the Drosophila zerknüllt (zen) and z2 genes, and like zen, are expressed only in extraembryonic membranes. We conclude that the zen genes of Drosophila derive from a Hox class 3 sequence that formed part of the common ancestral Hox cluster, but that in insects this (Hox) gene has lost its role in patterning the anterio-posterior axis of the embryo, and acquired a new function. In the lineage leading to Drosophila, the zen genes have diverged particularly rapidly.

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  • Gehring WJ, Qian YQ, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, Affolter M, Otting G, Wüthrich K. Homeodomain-DNA recognition. Cell. 1994 Jul 29;78(2):211–223. [PubMed]
  • Manak JR, Scott MP. A class act: conservation of homeodomain protein functions. Dev Suppl. 1994:61–77. [PubMed]
  • Slack JM, Holland PW, Graham CF. The zootype and the phylotypic stage. Nature. 1993 Feb 11;361(6412):490–492. [PubMed]
  • Holland PW, Holland LZ, Williams NA, Holland ND. An amphioxus homeobox gene: sequence conservation, spatial expression during development and insights into vertebrate evolution. Development. 1992 Nov;116(3):653–661. [PubMed]
  • Kaufman TC, Seeger MA, Olsen G. Molecular and genetic organization of the antennapedia gene complex of Drosophila melanogaster. Adv Genet. 1990;27:309–362. [PubMed]
  • Rushlow C, Levine M. Role of the zerknüllt gene in dorsal-ventral pattern formation in Drosophila. Adv Genet. 1990;27:277–307. [PubMed]
  • St Johnston D, Driever W, Berleth T, Richstein S, Nüsslein-Volhard C. Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte. Development. 1989;107 (Suppl):13–19. [PubMed]
  • Maggert K, Levine M, Frasch M. The somatic-visceral subdivision of the embryonic mesoderm is initiated by dorsal gradient thresholds in Drosophila. Development. 1995 Jul;121(7):2107–2116. [PubMed]
  • Lemaire P, Garrett N, Kato K, Gurdon JB. Construction of subtracted cDNA libraries enriched for cDNAs for genes expressed in the mesoderm of early Xenopus gastrulae. C R Acad Sci III. 1993 Sep;316(9):931–944. [PubMed]
  • Averof M, Akam M. HOM/Hox genes of Artemia: implications for the origin of insect and crustacean body plans. Curr Biol. 1993 Feb;3(2):73–78. [PubMed]
  • Cai H, Kiefel P, Yee J, Duncan I. A yeast artificial chromosome clone map of the Drosophila genome. Genetics. 1994 Apr;136(4):1385–1399. [PMC free article] [PubMed]
  • Brown SJ, Hilgenfeld RB, Denell RE. The beetle Tribolium castaneum has a fushi tarazu homolog expressed in stripes during segmentation. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12922–12926. [PMC free article] [PubMed]
  • Dawes R, Dawson I, Falciani F, Tear G, Akam M. Dax, a locust Hox gene related to fushi-tarazu but showing no pair-rule expression. Development. 1994 Jun;120(6):1561–1572. [PubMed]
  • Kappen C, Schughart K, Ruddle FH. Early evolutionary origin of major homeodomain sequence classes. Genomics. 1993 Oct;18(1):54–70. [PubMed]
  • Garcia-Fernández J, Holland PW. Archetypal organization of the amphioxus Hox gene cluster. Nature. 1994 Aug 18;370(6490):563–566. [PubMed]
  • Henikoff S. Gene silencing in Drosophila. Curr Top Microbiol Immunol. 1995;197:193–208. [PubMed]
  • Rushton E, Drysdale R, Abmayr SM, Michelson AM, Bate M. Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development. Development. 1995 Jul;121(7):1979–1988. [PubMed]
  • Stuart JJ, Brown SJ, Beeman RW, Denell RE. A deficiency of the homeotic complex of the beetle Tribolium. Nature. 1991 Mar 7;350(6313):72–74. [PubMed]
  • McGinnis W, Krumlauf R. Homeobox genes and axial patterning. Cell. 1992 Jan 24;68(2):283–302. [PubMed]
  • Rushlow C, Frasch M, Doyle H, Levine M. Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila. Nature. 1987 Dec 10;330(6148):583–586. [PubMed]
  • González-Crespo S, Morata G. Control of Drosophila adult pattern by extradenticle. Development. 1995 Jul;121(7):2117–2125. [PubMed]
  • Kapoun AM, Kaufman TC. A functional analysis of 5', intronic and promoter regions of the homeotic gene proboscipedia in Drosophila melanogaster. Development. 1995 Jul;121(7):2127–2141. [PubMed]
  • Means AL, Gudas LJ. The roles of retinoids in vertebrate development. Annu Rev Biochem. 1995;64:201–233. [PubMed]
  • Singh G, Kaur S, Stock JL, Jenkins NA, Gilbert DJ, Copeland NG, Potter SS. Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706–10710. [PMC free article] [PubMed]
  • Valerius MT, Li H, Stock JL, Weinstein M, Kaur S, Singh G, Potter SS. Gsh-1: a novel murine homeobox gene expressed in the central nervous system. Dev Dyn. 1995 Jul;203(3):337–351. [PubMed]
  • Krumlauf R. Evolution of the vertebrate Hox homeobox genes. Bioessays. 1992 Apr;14(4):245–252. [PubMed]
  • Akam M, Averof M, Castelli-Gair J, Dawes R, Falciani F, Ferrier D. The evolving role of Hox genes in arthropods. Dev Suppl. 1994:209–215. [PubMed]
  • van den Heuvel M, Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R. Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J. 1993 Dec 15;12(13):5293–5302. [PMC free article] [PubMed]

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