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Proc Natl Acad Sci U S A. 1986 Oct; 83(20): 7821–7825.
PMCID: PMC386814

Toward a physical map of the genome of the nematode Caenorhabditis elegans


A technique for digital characterization and comparison of DNA fragments, using restriction enzymes, is described. The technique is being applied to fragments from the nematode Caenorhabditis elegans (i) to facilitate cross-indexing of clones emanating from different laboratories and (ii) to construct a physical map of the genome. Eight hundred sixty clusters of clones, from 35 to 350 kilobases long and totaling about 60% of the genome, have been characterized.

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Selected References

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