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Proc Natl Acad Sci U S A. 1979 May; 76(5): 2222–2226.
PMCID: PMC383570

Cloning in Escherichia coli and physical structure of hepatitis B virion DNA.


A restriction map of hepatitis B virion DNA was established after cloning of the whole viral genome in Escherichia coli. By use of EcoRI, Xho I, Bgl II, Xba I, BamHI, HincII, and Hae III endonucleases, a total of 28 restriction sites were mapped. The single-stranded region was localized on the restriction map and 5' end of the short strand was mapped at a fixed position.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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