Logo of jvirolPermissionsJournals.ASM.orgJournalJV ArticleJournal InfoAuthorsReviewers
J Virol. Jun 1970; 5(6): 801–816.
PMCID: PMC376073

Morphogenesis of Bittner Virus


The morphogenesis of Bittner virus (mouse mammary tumor virus) was studied in sectioned mammary tumor cells. Internal components of the virus (type A particles) were seen being assembled in virus factories close to the nucleus and were also seen forming at the plasma membrane. The particles in virus factories became enveloped by budding through the membrane of cytoplasmic vacuoles which were derived from dilated endoplasmic reticulum. Complete virus particles were liberated from these vacuoles by cell lysis. Particles budding at the plasma membrane were released into intercellular spaces. Maturation of enveloped virus occurred after release, but mature internal components were rarely seen in the cytoplasm before envelopment. Direct cell-to-cell transfer of virus by pinocytosis of budding particles by an adjacent cell was observed, and unusual forms of budding virus which participated in this process are illustrated and described. There was evidence that some virus particles contained cytoplasmic constituents, including ribosomes. Certain features of the structure of internal components are discussed in relation to a recently proposed model for the internal component of the mouse leukemia virus. Intracisternal virus-like particles were occasionally seen in tumor cells, but there was no evidence that these structures were developmentally related to Bittner virus.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (11M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BERNHARD W. Electron microscopy of tumor cells and tumor viruses; a review. Cancer Res. 1958 Jun;18(5):491–509. [PubMed]
  • De Tkaczevski L, De Harven E, Friend C. Structure and leukemogenic activity of a murine leukemia virus. J Virol. 1968 Apr;2(4):365–375. [PMC free article] [PubMed]
  • Dmochowski L, Seman G, Gallager HS. Viruses as possible etiologic factors in human breast cancer. Cancer. 1969 Dec;24(6):1241–1249. [PubMed]
  • Gay FW, Clarke JK, Dermott E. Direct cell to cell transfer of Bittner virus. J Gen Virol. 1970 Apr;7(1):75–79. [PubMed]
  • GOLDFEDER A, GELBER D, MOORE DH. An electron microscope study of spontaneous mammary carcinomas in a subline of strain DBA mice. J Natl Cancer Inst. 1960 Oct;25:827–845. [PubMed]
  • Hall WT, Hartley JW, Sanford KK. Characteristics of and relationship between C particles and intracisternal A particles in cloned cell strains. J Virol. 1968 Mar;2(3):238–247. [PMC free article] [PubMed]
  • Kakefuda T, Bader JP. Electron microscopic observations on the ribonucleic acid of murine leukemia virus. J Virol. 1969 Oct;4(4):460–474. [PMC free article] [PubMed]
  • Lyons MJ, Moore DH. Isolation of the mouse mammary tumor virus: chemical and morphological studies. J Natl Cancer Inst. 1965 Sep;35(3):549–565. [PubMed]
  • Moore DH, Charney J, Lasfargues EY, Sarkar NH, Rubin RC, Ames RP. Mammary tumor virus (MTV) virions in a transplantable ependymoblastoam. Proc Soc Exp Biol Med. 1969 Oct;132(1):125–127. [PubMed]
  • Nii S, Morgan C, Rose HM. Electron microscopy of herpes simplex virus. II. Sequence of development. J Virol. 1968 May;2(5):517–536. [PMC free article] [PubMed]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...