Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
PMC full text:
Nat Genet. Author manuscript; available in PMC 2013 Jul 30.
Published in final edited form as:
Nat Genet. 2012 May 29; 44(6): 623–630.
Published online 2012 May 29. doi:  10.1038/ng.2303

Figure 2

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Association analysis. (a) Q-Q plot of association p-values under the null hypothesis. (b) Distributions of lowest p-values under whole-exome permutations. The histograms show the distributions of the lowest p-values across permutations for the T5 test. The red vertical line indicates the 0.05 exome-wide significance level for the most significant gene (i.e., the most significant gene is exome-wide significant if its p-value is lower that the level indicated by the red line).

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