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JRSM Short Rep. 2013 Jun; 4(6): 2042533313479197.
Published online 2013 May 7. doi:  10.1177/2042533313479197
PMCID: PMC3697857

Using mixed methods in health research


Mixed methods research is the use of quantitative and qualitative methods in a single study or series of studies. It is an emergent methodology which is increasingly used by health researchers, especially within health services research. There is a growing literature on the theory, design and critical appraisal of mixed methods research. However, there are few papers that summarize this methodological approach for health practitioners who wish to conduct or critically engage with mixed methods studies. The objective of this paper is to provide an accessible introduction to mixed methods for clinicians and researchers unfamiliar with this approach. We present a synthesis of key methodological literature on mixed methods research, with examples from our own work and that of others, to illustrate the practical applications of this approach within health research. We summarize definitions of mixed methods research, the value of this approach, key aspects of study design and analysis, and discuss the potential challenges of combining quantitative and qualitative methods and data. One of the key challenges within mixed methods research is the successful integration of quantitative and qualitative data during analysis and interpretation. However, the integration of different types of data can generate insights into a research question, resulting in enriched understanding of complex health research problems.


Mixed methods research is the use of quantitative and qualitative methods in one study. Research is often dichotomized as quantitative or qualitative. Quantitative research, such as clinical trials or observational studies, generates numerical data. On the other hand qualitative approaches tend to generate non-numerical data, using methods such as semi-structured interviews, focus group discussions and participant observation. Historically, quantitative methods have dominated health research. However, qualitative methods have been increasingly accepted by the health research community in the past two decades, with a rise in publication of qualitative studies.1 As the value of qualitative approaches has been recognized, there has been a growing interest in combining qualitative and quantitative methods. A recent review of health services research within England has shown an increase in the proportion of studies classified as mixed methods from 17% in the mid-1990s to 30% in the early 2000s.2 In this paper, we present a synthesis of key literature on mixed methods research, with examples from our own work and that of others to illustrate the practical applications of this approach. This paper is aimed at health researchers and practitioners who are new to the field of mixed methods research and may only have experience of either quantitative or qualitative approaches and methodologies. We wish to provide these readers with an accessible introduction to the increasingly popular methodology of mixed methods research. We hope this will help readers to consider whether their research questions might best be answered by a mixed methods study design, and to engage critically with health research that uses this approach.


The authors each independently carried out a narrative literature review and met to discuss findings. Literature was identified via searches of PubMed, Google and Google Scholar, and hand-searches of the Journal of Mixed Methods Research, with relevant publications selected after discussion. An important consideration was that papers either had a methodological focus or contained a detailed description of their mixed methods design. For PubMed and Google searches, similar terms were used. For example, the PubMed strategy consisted of title and abstract searches for: ((mixed methods) OR ((mixed OR (qualitative AND quantitative)) AND methods)). We also drew upon recommendations from mixed methods conferences and seminars, and reference lists from key publications.

What is mixed methods research?

The most widely accepted definition of mixed methods research is research that ‘focuses on collecting, analysing, and mixing both quantitative and qualitative data in a single study or a series of studies’.3 Central to the definition is the use of both quantitative and qualitative methods in one study (or a series of connected studies). Separate quantitative and qualitative studies addressing the same research question independently would not be considered ‘mixed methods’ as there would be no integration of approaches at the design, analysis or presentation stage. A recent innovation in mixed methods research is the mixed methods systematic review, which sets out to systematically appraise both quantitative and qualitative literature on a subject area and then synthesize the findings.

Why are mixed methods approaches used?

The underlying assumption of mixed methods research is that it can address some research questions more comprehensively than by using either quantitative or qualitative methods alone.3 Questions that profit most from a mixed methods design tend to be broad and complex, with multiple facets that may each be best explored by quantitative or qualitative methods. See Boxes 1 and and22 for examples from our own work.

Box 1.
Examples of authors’ mixed methods research – JW.
Box 2.
Examples of authors’ mixed methods research – ST.

Usually, quantitative research is associated with a positivist stance and a belief that reality that can be measured and observed objectively. Most commonly, it sets out to test an a priori hypothesis and is therefore conventionally described as ‘deductive’. Strengths of quantitative research include its procedures to minimize confounding and its potential to generate generalizable findings if based on samples that are both large enough and representative. It remains the dominant paradigm in health research. However, this deductive approach is less suited to generating hypotheses about how or why things are happening, or explaining complex social or cultural phenomena.

Qualitative research most often comes from an interpretive framework and is usually informed by the belief that there are multiple realities shaped by personal viewpoints, context and meaning. In-depth qualitative research aims to provide a rich description of views, beliefs and meaning. It also tends to acknowledge the role of researcher and context in shaping and producing the data. Qualitative approaches are described as ‘inductive’ as questions are often open-ended with the analysis allowing hypotheses to emerge from data. High-quality qualitative research can generate robust theory that is applicable to contexts outside of the study area in question, helping to guide practitioners and policy-makers.8 However, for research that aims to directly impact on policy and practice, the findings of qualitative research can be limited by the small sample sizes that are necessary for in-depth exploratory work and the consequent lack of generalizabilty.

Mixed methods research therefore has the potential to harness the strengths and counterbalance the weaknesses of both approaches and can be especially powerful when addressing complex, multifaceted issues such as health services interventions9 and living with chronic illness.10

There are many reasons why researchers choose to combine quantitative and qualitative methods in a study.11,12 We list some common reasons below, using a hypothetical research question about adolescents’ adherence to anticonvulsant medication to illustrate real world applications.

  • Complementarity: Using data obtained by one method to illustrate results from another. An example of this would be a survey of adolescents with epilepsy demonstrating poor levels of adherence. Semi-structured interviews with a sub-group of those surveyed may allow us to explore barriers to adherence.
  • Development: Using results from one method to develop or inform the use of the other method. A focus group conducted with a group of adolescents with epilepsy may identify mobile phone technology as a potentially important tool in adherence support. We could then develop a mobile phone ‘app’ that reminds patients to take their medication and conduct an intervention study to assess its impact on adherence levels.
  • Initiation: Using results from different methods specifically to look for areas of incongruence in order to generate new insights. An illustration of this would be a study exploring the discrepancy between reported adherence in clinic consultations and actual medication adherence. A review of case notes may find adherence levels of over 90% in a clinic population; however, semi-structured interviews with peer researchers may reveal lower levels of adherence and barriers to open discussion with clinicians.
  • Expansion: Setting out to examine different aspects of a research question, where each aspect warrants different methods. We may wish to conduct a study that explores adherence more broadly. A large-scale survey of adolescents with epilepsy would provide information on adherence levels and associations whilst interviews and focus groups may allow us to engage with individual experiences of chronic illness and medication in adolescence.
  • Triangulation: Using data obtained by both methods to corroborate findings. For example, we could conduct a clinical study measuring drug levels in individuals and documenting self-reported adherence. Qualitative methods such as video diaries may confirm adherence levels.

To this list we would also add political commitment. That is to say, researchers may recognize, and wish to deploy, the strengths of quantitative research in producing generalizable results but may also be committed to representing the voice of participants in their work.

Whatever the reasons for mixing methods, it is important that authors present these explicitly as it allows us to assess if a mixed methods study design is appropriate for answering the research question.3,13

How is mixed methods research conducted?

When embarking on a mixed methods research project it is important to consider:

  • the methods that will be used;
  • the priority of the methods;
  • the sequence in which the methods are to be used.

A wide variety of methods exists by which to collect both quantitative and qualitative data. Both the research question and the data required will be the main determinants of the methods used. To a lesser extent, the choice of methods may be influenced by feasibility, the research team’s skills and experience and time constraints.

Priority of methods relates to the emphasis placed on each method in the study. For instance, the study may be predominantly a quantitative study with a small qualitative component, or vice versa. Alternatively, both quantitative and qualitative methods and data may have equal weighting. The emphasis given to each component of the study will be driven mainly by the research question, the skills of the research team and feasibility.

Finally, researchers must decide when each method is to be used in the study. For instance a team may choose to start with a quantitative phase followed by a qualitative phase, or vice versa. Some studies use both quantitative and qualitative methods concurrently. Again the choice of when to use each method is largely dependent on the research question.

The priority and sequence of mixing methods have been elaborated in a typology of mixed methods research models. See Table 1 for typology and specific examples.

Table 1.
Examples of studies using mixed methods.

How is data analysed in a mixed methods project?

The most important, and perhaps most difficult, aspect of mixed methods research is integrating the qualitative and quantitative data. One approach is to analyse the two data types separately and to then undertake a second stage of analysis where the data and findings from both studies are compared, contrasted and combined.19 The quantitative and qualitative data are kept analytically distinct and are analysed using techniques usually associated with that type of data; for example, statistical techniques could be used to analyse survey data whilst thematic analysis may be used to analyse interview data. In this approach, the integrity of each data is preserved whilst also capitalizing on the potential for enhanced understanding from combining the two data and sets of findings.

Another approach to mixed methods data analysis is the integrative strategy.20 Rather than keeping the datasets separate, one type of data may be transformed into another type. That is to say that qualitative data may be turned into quantitative data (‘quantitizing’) or quantitative data may be converted into qualitative data (‘qualitizing’).21 The former is probably the most common method of this type of integrated analysis. Quantitative transformation is achieved by the numerical coding of qualitative data to create variables that may relate to themes or constructs, allowing statements such as ‘six of 10 participants spoke of the financial barriers to accessing health care’. These data can then be combined with the quantitative dataset and analysed together. Transforming quantitative data into qualitative data is less common. An example of this is the development of narrative psychological ‘types’ from numerical data obtained by questionnaires.22

Potential challenges in conducting mixed methods research

Despite its considerable strengths as an approach, mixed methods research can present researchers with challenges.23,24

Firstly, combining methodologies has sometimes been seen as problematic because of the view that quantitative and qualitative belong to separate and incompatible paradigms. In this context, paradigms are the set of practices and beliefs held by an academic community at a given point in time.25 Researchers subscribing to this view argue that it is neither possible nor desirable to combine quantitative and qualitative methods in a study as they represent essentially different and conflicting ways of viewing the world and how we collect information about it.8 Other researchers take a more pragmatic view, believing that concerns about the incommensurability of worldviews can be set aside if the combination of quantitative and qualitative methods addresses the research question effectively. This pragmatic view informs much applied mixed methods research in health services or policy.8

Secondly, combining two methods in one study can be time consuming and requires experience and skills in both quantitative and qualitative methods. This can mean, in reality, that a mixed methods project requires a team rather than a lone researcher in order to conduct the study rigorously and within the specified time frame. However, it is important that a team comprising members from different disciplines work well together, rather than becoming compartmentalized.26 We believe that a project leader with experience in both quantitative and qualitative methods can act as an important bridge in a mixed methods team.

Thirdly, achieving true integration of the different types of data can be difficult. We have suggested various analytic strategies above but this can be hard to achieve as it requires innovative thinking to move between different types of data and make meaningful links between them. It is therefore important to reflect on the results of a study and ask if your understanding has been enriched by the combination of different types of data. If this is not the case then integration may not have occurred sufficiently.23

Finally, many researchers cite the difficulty in presenting the results of mixed methods study as a barrier to conducting this type of research.23 Researchers may decide to present their quantitative and qualitative data separately for different audiences. This strategy may involve a decision to publish additional work focusing on the interpretations and conclusions which come from comparing and contrasting findings from the different data types. See Box 1 for an example of this type of publication strategy. Many journals in the medical sciences have a distinct methodological base and relatively restrictive word limits which may preclude the publication of complex, mixed methods studies. However, as the number of mixed methods studies increases in the health research literature we would expect researchers to feel more confident in the presentation of this type of work.


Many of the areas we explore in health are complex and multifaceted. Mixed methods research (combining quantitative and qualitative methods in one study) is an innovative and increasingly popular way of addressing these complexities. Although mixed methods research presents some challenges, in much the same way as every methodology does, this approach provides the research team with a wider range of tools at their disposal in order to answer a question. We believe that the production and integration of different types of data and the combination of skill sets in a team can generate insights into a research question, resulting in enriched understanding.


Competing interests

None declared


This work was funded by the Medical Research Council (MRC) [grant number: G0701648 to ST], and the MRC with the Economic and Social Research Council (ESRC) [grant number: G0800112 to JW]

Ethical approval

No ethical approval was required for this work




This work was conceived by both ST and JW who each carried out an independent literature review and collaborated on the structure and content of this report. ST wrote the manuscript with revisions and editing done by JW


We thank Professors Jonathan Elford and Ruth Gilbert for their comments on draft manuscripts


This article was submitted by the authors and peer reviewed by Geoffrey Harding


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