Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
PMC full text:
Cell. Author manuscript; available in PMC 2014 Apr 25.
Published in final edited form as:
Cell. 2013 Apr 25; 153(3): 666–677.
doi:  10.1016/j.cell.2013.03.021

Figure 1

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Somatic Alterations in 57 Prostate Tumor Genomes

WGS was conducted on 55 prostate adenocarcinomas and two lung metastases from neuroendocrine prostate cancers (NEPC, *) along with paired normal DNA to detect somatic rearrangements and mutations. Gains and losses of DNA copy number at sites of recurrent SNCAs were detected with Affymetrix SNP 6.0 arrays (recurrent SCNAs were not assessed for sample P07-144, hatched lines). Bottom, cancer DNA purity was evaluated by assessing allelic ratios from sequence reads covering heterozygous single-nucleotide polymorphisms at sites of chromosomal deletion (Supplemental Experimental Procedures). ETS gene fusions (ERG, ETV1) were detected by sequencing and validated by fluorescence in situ hybridization (FISH).

See also Tables S14 and Figure S1.

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