Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
PMC full text:
J Vestib Res. Author manuscript; available in PMC 2013 Jun 24.
Published in final edited form as:
J Vestib Res. 2011; 21(6): 305–314.
doi:  10.3233/VES-2012-0433

Fig. 2

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Proposed mechanism of action for COX1/COX2 inhibitors during migraine. (a) After the establishment of central sensitization, the pain throbs (●) and the skin is allodynic (●). (b) At this stage, COX1/COX2 inhibitors reverse the sensitization of both the peripheral and central trigeminovascular neurons, resulting in termination of pain, throbbing and allodynia (○).

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