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Mol Cell Biol. Nov 1990; 10(11): 6073–6078.
PMCID: PMC361409

Altered transcriptional activity of c-fos promoter plasmids in v-raf-transformed NIH 3T3 cells.

Abstract

In cells transformed by v-raf, an oncogenic counterpart of the serine/threonine kinase Raf-1, regulatory elements of the c-fos promoter were active under conditions of cell growth or stimulation for which they were inactive in untransformed control cells. This suggests that v-raf transforms by deregulating transcription of early response genes.

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Selected References

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