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Mol Cell Biol. Aug 1990; 10(8): 4365–4369.
PMCID: PMC360988

bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.


Lymphoid cells transformed by temperature-sensitive Abelson virus die at the nonpermissive temperature. This property was exploited to show that bcr/abl and v-src but not myc and ras can replace the transforming signal of v-abl, a result suggesting that the former but not the latter oncogenes transform lymphoid cells via a similar pathway.

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Selected References

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  • Alexander WS, Adams JM, Cory S. Oncogene cooperation in lymphocyte transformation: malignant conversion of E mu-myc transgenic pre-B cells in vitro is enhanced by v-H-ras or v-raf but not v-abl. Mol Cell Biol. 1989 Jan;9(1):67–73. [PMC free article] [PubMed]
  • Borzillo GV, Sherr CJ. Early pre-B-cell transformation induced by the v-fms oncogene in long-term mouse bone marrow cultures. Mol Cell Biol. 1989 Sep;9(9):3973–3981. [PMC free article] [PubMed]
  • Chesebro B, Wehrly K, Cloyd M, Britt W, Portis J, Collins J, Nishio J. Characterization of mouse monoclonal antibodies specific for Friend murine leukemia virus-induced erythroleukemia cells: friend-specific and FMR-specific antigens. Virology. 1981 Jul 15;112(1):131–144. [PubMed]
  • Cleveland JL, Jansen HW, Bister K, Fredrickson TN, Morse HC, 3rd, Ihle JN, Rapp UR. Interaction between Raf and Myc oncogenes in transformation in vivo and in vitro. J Cell Biochem. 1986;30(3):195–218. [PubMed]
  • Clynes R, Wax J, Stanton LW, Smith-Gill S, Potter M, Marcu KB. Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6067–6071. [PMC free article] [PubMed]
  • Colledge WH, Gebhardt A, Edge MD, Bell JC. Analysis of A-MuLV transformed fibroblast lines for amplification of the c-myc, p53 and c-fos nuclear proto-oncogenes. Oncogene. 1989 Jun;4(6):753–757. [PubMed]
  • Daley GQ, McLaughlin J, Witte ON, Baltimore D. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts. Science. 1987 Jul 31;237(4814):532–535. [PubMed]
  • Engelman A, Rosenberg N. Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8021–8025. [PMC free article] [PubMed]
  • Furth ME, Davis LJ, Fleurdelys B, Scolnick EM. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J Virol. 1982 Jul;43(1):294–304. [PMC free article] [PubMed]
  • Gebhardt A, Bell JC, Foulkes JG. Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice. EMBO J. 1986 Sep;5(9):2191–2195. [PMC free article] [PubMed]
  • Green PL, Kaehler DA, Bennett LM, Risser R. Multiple steps are required for the induction of tumors by Abelson murine leukemia virus. J Virol. 1989 May;63(5):1989–1994. [PMC free article] [PubMed]
  • Kizaka S, Hakura A. A cell mutant that exhibits temperature-dependent sensitivity to transformation by various oncogenes. Mol Cell Biol. 1989 Dec;9(12):5669–5675. [PMC free article] [PubMed]
  • Liu E, Hjelle B, Bishop JM. Transforming genes in chronic myelogenous leukemia. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1952–1956. [PMC free article] [PubMed]
  • Lugo TG, Witte ON. The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc. Mol Cell Biol. 1989 Mar;9(3):1263–1270. [PMC free article] [PubMed]
  • McCubrey J, Holland G, McKearn J, Risser R. Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms. Oncogene Res. 1989;4(2):97–109. [PubMed]
  • McLaughlin J, Chianese E, Witte ON. In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6558–6562. [PMC free article] [PubMed]
  • Morrison DK, Kaplan DR, Rapp U, Roberts TM. Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8855–8859. [PMC free article] [PubMed]
  • Nepveu A, Fahrlander PD, Yang JQ, Marcu KB. Amplification and altered expression of the c-myc oncogene in A-MuLV-transformed fibroblasts. Nature. 1985 Oct 3;317(6036):440–443. [PubMed]
  • Parsons SJ, McCarley DJ, Ely CM, Benjamin DC, Parsons JT. Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin. J Virol. 1984 Aug;51(2):272–282. [PMC free article] [PubMed]
  • Pierce JH, Aaronson SA. In vitro transformation of murine pre-B lymphoid cells by Snyder-Theilen feline sarcoma virus. J Virol. 1983 Jun;46(3):993–1002. [PMC free article] [PubMed]
  • Pierce JH, Aaronson SA, Anderson SM. Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2374–2378. [PMC free article] [PubMed]
  • Rosenberg N, Baltimore D. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med. 1976 Jun 1;143(6):1453–1463. [PMC free article] [PubMed]
  • Rosenberg N, Witte ON. The viral and cellular forms of the Abelson (abl) oncogene. Adv Virus Res. 1988;35:39–81. [PubMed]
  • Schiff-Maker L, Burns MC, Konopka JB, Clark S, Witte ON, Rosenberg N. Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules. J Virol. 1986 Mar;57(3):1182–1186. [PMC free article] [PubMed]
  • Schwartz RC, Stanton LW, Riley SC, Marcu KB, Witte ON. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol Cell Biol. 1986 Sep;6(9):3221–3231. [PMC free article] [PubMed]
  • Smith MR, DeGudicibus SJ, Stacey DW. Requirement for c-ras proteins during viral oncogene transformation. Nature. 1986 Apr 10;320(6062):540–543. [PubMed]
  • Vogt M, Lesley J, Bogenberger J, Volkman S, Haas M. Coinfection with viruses carrying the v-Ha-ras and v-myc oncogenes leads to growth factor independence by an indirect mechanism. Mol Cell Biol. 1986 Oct;6(10):3545–3549. [PMC free article] [PubMed]
  • Witte ON, Rosenberg N, Baltimore D. Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface. J Virol. 1979 Sep;31(3):776–784. [PMC free article] [PubMed]

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