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Antimicrob Agents Chemother. 1979 January; 15(1): 28–33. | PMCID: PMC352595 |
Pharmacokinetics of Amoxicillin: Dosage Nomogram for Patients with Impaired Renal Function Guy Humbert,1 Daniel A. Spyker,2 J. P. Fillastre,3 and Annie Leroy1 1Department of Infectious Diseases University of Rouen, School of Medicine, Rouen, France 3Department of Nephrology, University of Rouen, School of Medicine, Rouen, France 2Department of Internal Medicine, Division of Clinical Pharmacology, University of Virginia, School of Medicine, Charlottesville, Virginia 22901 Abstract Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected creatinine clearance of 100 ml/min per 70 kg and 16 h in the anephric patient. Average amoxicillin half-life on hemodialysis was 3.6 h. We present a dosage nomogram for making appropriate adjustments to loading dose based on patient weight and maintenance dose based on corrected creatinine clearance. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (758K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Bryan CS, Stone WJ. "Comparably massive" penicillin G therapy in renal failure. Ann Intern Med. 1975 Feb;82(2):189–195. [PubMed]
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