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Antimicrob Agents Chemother. 1978 October; 14(4): 539–543. | PMCID: PMC352504 |
Pharmacokinetics of Amoxicillin and Ampicillin: Crossover Study of the Effect of Food Fred N. Eshelman1 and Daniel A. Spyker2 1Beecham Laboratories, Bristol, Tennessee 37620, 2Department of Internal Medicine, Division of Clinical Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 Abstract The effect of food on the absorption of amoxicillin and ampicillin was studied in 16 normal subjects in a double-blind crossover study after each subject was given a single oral 500-mg dose. Serum drug levels were analyzed, assuming a one-compartment linear model with first-order absorption and absorption delay, area under the curve, and urinary recovery. Variations in kinetic parameters were examined by using analysis of variance. The results showed little or no effect of fasting versus nonfasting on amoxicillin absorption, as evidenced by peak serum levels (8.9 μg/ml, fasting, 8.8 μg/ml, nonfasting), area under the curve (26.9 μg/ml per 70 kg, fasting, 22.2 μg/ml per 70 kg, nonfasting), and urinary recovery (47%, fasting; 44%, nonfasting). Ampicillin absorption was significantly decreased in the nonfasted group by the same parameters (peak level: 5.4 μg/ml, fasting, 4.0 μg/ml, nonfasting; area under the curve, 17.4 h·μg/ml, fasting, 12.0 h·μg/ml, nonfasting; urinary recovery, 37%, fasting, 29%, nonfasting). These results confirm the reliable absorption of orally administered amoxicillin in the fed as well as the fasted state. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (693K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Gordon C, Regamey C, Kirby WM. Comparative clinical pharmacology of amoxicillin and ampicillin administered orally. Antimicrob Agents Chemother. 1972 Jun;1(6):504–507. [PubMed]
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