• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. Dec 1982; 38(3): 921–924.
PMCID: PMC347837

Synergistic effect of Candida albicans and Staphylococcus aureus on mouse mortality.

Abstract

A synergistic effect on mouse mortality was demonstrated in combined infection of mice with Candida albicans and a Staphylococcus aureus strain isolated from a patient with toxic shock syndrome. Mice exhibited high resistance when inoculated intraperitoneally by either pathogen alone. Dual infection with the two organisms together, however, at doses which separately caused no animal deaths, resulted in 100% mortality. This synergistic effect could not be reproduced when either of the agents was heat inactivated.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (558K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BENNETT BM. Estimation of LD50 by moving averages. J Hyg (Lond) 1952 Jun;50(2):157–164. [PMC free article] [PubMed]
  • Castells S, Inamdar S, Orti E. Familial moniliasis, defective delayed hypersensitivity, and adrenocorticotropic hormone deficiency. J Pediatr. 1971 Jul;79(1):72–79. [PubMed]
  • Davis JP, Chesney PJ, Wand PJ, LaVenture M. Toxic-shock syndrome: epidemiologic features, recurrence, risk factors, and prevention. N Engl J Med. 1980 Dec 18;303(25):1429–1435. [PubMed]
  • Drake TE, Maibach HI. Candida and candidiasis. 1. Cultural conditions, epidemiology and pathogenesis. Postgrad Med. 1973 Feb;53(2):83–87. [PubMed]
  • Durack DT. Opportunistic infections and Kaposi's sarcoma in homosexual men. N Engl J Med. 1981 Dec 10;305(24):1465–1467. [PubMed]
  • Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med. 1981 Dec 10;305(24):1425–1431. [PubMed]
  • Hamilton JR, Overall JC, Glasgow LA. Synergistic effect on mortality in mice with murine cytomegalovirus and Pseudomonas aeruginosa, Staphylococcus aureus, or Candida albicans infections. Infect Immun. 1976 Oct;14(4):982–989. [PMC free article] [PubMed]
  • Hurley R. Inveterate vaginal thrush. Practitioner. 1975 Dec;215(1290):753–756. [PubMed]
  • Conway H. Emergency medical care. Br Med J. 1976 Aug 28;2(6034):511–513. [PMC free article] [PubMed]
  • KEENEY EL. Candida asthma. Ann Intern Med. 1951 Jan;34(1):223–226. [PubMed]
  • Lapan B. Is the "pill" a cause of vaginal candidiasis? Culture study. N Y State J Med. 1970 Apr 15;70(8):949–951. [PubMed]
  • LOURIA DB, FALLON N, BROWNE HG. The influence of cortisone on experimental fungus infections in mice. J Clin Invest. 1960 Sep;39:1435–1449. [PMC free article] [PubMed]
  • NEUFELD O, WALLBANK WL. Case of candida asthma and its management. J Mich State Med Soc. 1952 Nov;51(11):1419–1420. [PubMed]
  • Rogers TJ, Balish E. Immunity to Candida albicans. Microbiol Rev. 1980 Dec;44(4):660–682. [PMC free article] [PubMed]
  • ROTH FJ, Jr, FRIEDMAN J, SYVERTON JT. Effects of roentgen radiation and cortisone on susceptibility of mice to Candida albicans. J Immunol. 1957 Feb;78(2):122–127. [PubMed]
  • Russell C, Jones JH. Effects of oral inoculation of Candida albicans in tetracycline-treated rats. J Med Microbiol. 1973 Aug;6(3):275–279. [PubMed]
  • Schlievert PM, Osterholm MT, Kelly JA, Nishimura RD. Toxin and enzyme characterization of Staphylococcus aureus isolates from patients with and without toxic shock syndrome. Ann Intern Med. 1982 Jun;96(6 Pt 2):937–940. [PubMed]
  • Shannon DC, Johnson G, Rosen FS, Austen KF. Cellular reactivity to Candida albicans antigen. N Engl J Med. 1966 Sep 29;275(13):690–693. [PubMed]
  • SONCK CE, SOMERSALO O. THE YEAST FLORA OF THE ANOGENITAL REGION IN DIABETIC GIRLS. Arch Dermatol. 1963 Dec;88:846–852. [PubMed]
  • Todd J, Fishaut M, Kapral F, Welch T. Toxic-shock syndrome associated with phage-group-I Staphylococci. Lancet. 1978 Nov 25;2(8100):1116–1118. [PubMed]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

Formats:

Related citations in PubMed

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...