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Indian J Surg. Apr 2009; 71(2): 73–77.
Published online May 2, 2009. doi:  10.1007/s12262-009-0020-9
PMCID: PMC3452607

The effect of Kombucha on post-operative intra-abdominal adhesion formation in rats

Abstract

Background

Peritoneal adhesions are fibrous bands of tissues formed between organs that are normally separated and/or between organs and the internal body wall after peritoneal injury. The aim of the study was to investigate the effect of intra-peritoneal administration of Kombucha on intra-peritoneal adhesions.

Materials and methods

Eighty Wistar rats were subjected to standardized lesion by scraping model and were randomly divided into two groups. Group I received no treatment, and Group II received 15 ml of Kombucha solution intra-peritoneally. On the post-operative 14th day adhesion intensity score, inflammatory cell reaction and number of adhesion bands were determined.

Results

In the control group, there were no rats with grade 0 and I adhesions. In the group II, there were 26 rats (78.8%) with grade 0–2 adhesions. Adhesion intensity was significantly less in group II (P<0.0001). Number of adhesion bands was significantly less in group II (P<0.001).

Conclusion

It was concluded that intra-peritoneal administration of Kombucha might be useful for preventing peritoneal adhesions.

Full Text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Ellis H., Moran B., Thompson J. Adhesion related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet. 1999;353:1476–1480. doi: 10.1016/S0140-6736(98)09337-4. [PubMed] [Cross Ref]
2. Cheong Y.C., Laird S.M., Li T.C., Shelton J.B., Ledger W.L., Cooke I.D. Peritoneal healing and adhesion formation/reformation. Hum Reprod. 2001;7(6):556–566. doi: 10.1093/humupd/7.6.556. [PubMed] [Cross Ref]
3. DiZerega G.S., Campeau J.D. Peritoneal repair and postsurgical adhesion formation. Hum Reprod Update. 2001;7(6):547–555. doi: 10.1093/humupd/7.6.547. [PubMed] [Cross Ref]
4. Milligan D.W., Raftery A.T. Observations on the pathogenesis of peritoneal adhesions: a fight and electron microscopically study. Br J Surg. 1974;61:274–280. doi: 10.1002/bjs.1800610406. [PubMed] [Cross Ref]
5. DiZerega GS. The peritoneum and its response to surgical injury. In: diZerega ZG, Malinak L, Diamond M, Linsky C, editors. Treatment of post-surgical adhesions. New York: Wiley Liss. pp 166–171.
6. Nair S., Bhat I., Aurora A. Role of proteolytic enzyme in the prevention of post-operative intraperitoneal adhesions. Arch Surg. 1974;108:849–853. [PubMed]
7. Menzies D., Ellis H. Intestinal obstruction from adhesions. How big is the problem? Ann R Coll Surg Engl. 1990;72:60–63. [PMC free article] [PubMed]
8. Ellis H. The cause and prevention of post-operative intraperitoneal adhesions. Surg Gynecol Obstet. 1971;133:497–511. [PubMed]
9. Hers A., Diamond M.P., DeCherney A.H. Adhesiolysis. Clin Obstet Gynecol. 1991;34:395–398. doi: 10.1097/00003081-199106000-00023. [PubMed] [Cross Ref]
10. Afyez J.A. An assessment of the role of operative laparoscopy in tuboplasty. Fertil Steril. 1983;39:476–479. [PubMed]
11. Ellis H. The causes and prevention of intestinal adhesions. Br J Surg. 1982;68:241–243. doi: 10.1002/bjs.1800690502. [PubMed] [Cross Ref]
12. Treutner K.H., Schumpelick V. Adhesion prevention. Wish and reality. Chirurg. 2000;71:510–517. doi: 10.1007/s001040050848. [PubMed] [Cross Ref]
13. Alponat A., Lakshminarasappa S.R., Yavuz N., Goh P.M. Prevention of adhesions by Seprafilm, an absorbable adhesion barrier: an incisional hernia model in rats. Am Surg. 1997;63:818–819. [PubMed]
14. Frank GK (1996) Healthy beverage from the Far East. Its correct preparation and use. Ennsthaler. Steyr.
15. Blance P (1995) Research on tea fungus. Draft of research article posted to Kombucha Discussion list.
16. Larsson B., Svanberg S.G., Swolin K. Oxyphen-butazone, an adjuvant to be used in prevention of adhesion in operations for fertility. Fertil Steril. 1977;28:807–809. [PubMed]
17. Luciano A.A., Hauser, Benda J. Evaluation of commonly used adjuvants in the prevention of postoperative adhesions. Am J Obstet Gynecol. 1983;146:88–91. [PubMed]
18. Elkins T.E., Bury R.J., Ritter J.I. Adhesion prevention by solutions of sodium carboxymethyl cellulose in rat. Fertil Steril. 1984;41:926–928. [PubMed]
19. Evans D.M., Mc Aree K., Guyton D.P. Dose dependency and wound healing aspects of the use of tissue plasminogen activator in the prevention of intra-abdominal adhesions. Am J Surg. 1993;165:229–232. doi: 10.1016/S0002-9610(05)80516-1. [PubMed] [Cross Ref]
20. Dijkstra F.R., Nieuwenhuijzen M., Reijnen M.M., et al. Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intr-abdominal adhesions. Scand J Gastroenterol SUPPL. 2000;232:52. [PubMed]
21. Cheong Y.C., Laird S.M., Shellton J.B. The correlation of adhesions and peritoneal fluid cytokine concentrations: A pilot study. Hum Reprod. 2002;17:1039. doi: 10.1093/humrep/17.4.1039. [PubMed] [Cross Ref]
22. Costain D.J., Kennedy R., Ciona C., Mc Alister V.C. Prevention of postsurgical adhesions with N,O-carboxymethyl chitosan: examination of the most efficacious preparation and the effect of N,O-carboxymethyl chitosan healing. Surgery. 1997;121:314–319. doi: 10.1016/S0039-6060(97)90360-3. [PubMed] [Cross Ref]
23. Kennedy R., Costain D.J., Mc Alister V.C. Prevention of experimental post-operative peritoneal adhesions by N,O-carboxymethyl chitosan. Surgery. 1996;120:866–870. doi: 10.1016/S0039-6060(96)80096-1. [PubMed] [Cross Ref]
24. Ozogul Y., Baykal A., Onat D., Renda N., Sayek I. An experimental study of the effect of Aprotinin on intestinal adhesion formation. Am J Surg. 1998;175:137–141. doi: 10.1016/S0002-9610(97)00273-0. [PubMed] [Cross Ref]
25. Kagoma P., Burger S.N., Seifter E., Levenson S.M., Achilles A. The effect of vitamin E on experimentally induced peritoneal adhesions in mice. Arch Surg. 1985;120:949–951. [PubMed]
26. Snoj M., Ar’Rajab A., Ahren B., Larsson K., Bengmark S. Phospholipase-resistant phosphatidylcholine reduces intra-abdominal adhesions induced by bacterial peritonitis. Res Exp Med. 1993;193:117–122. doi: 10.1007/BF02576218. [PubMed] [Cross Ref]
27. Nagler A., Rivkind A.I., Raphael J., Schaffer F.L., Genina O. Halofuginone—an inhibitor of collagen type I synthesis—prevents post-operative formation of abdominal adhesions. Ann Surg. 1998;227:575–582. doi: 10.1097/00000658-199804000-00021. [PMC free article] [PubMed] [Cross Ref]
28. Galili Y., Abraham R.B., Rabau M., Klausner J., Kluger Y. Reduction of surgery induced peritoneal adhesions by methylene blue. Am J Surg. 1998;75:30–32. doi: 10.1016/S0002-9610(97)00232-8. [PubMed] [Cross Ref]
29. Roussin M (1996) Out on the Kombucha range. Post to Kombucha Discussion list.

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