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Proc Natl Acad Sci U S A. Sep 1978; 75(9): 4436–4440.
PMCID: PMC336130

Evidence that spontaneous mitotic recombination occurs at the two-strand stage.

Abstract

Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mitosis. The associated heteroallelic recombination frequently reflects the formation of symmetric Holliday structures, is not strongly polarized with respect to conversion at the heteroallelic trp5 sites studied, occasionally results in simultaneous conversion of widely separated genetic markers, and is positively correlated with recombination of flanking markers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Stern C. Somatic Crossing over and Segregation in Drosophila Melanogaster. Genetics. 1936 Nov;21(6):625–730. [PMC free article] [PubMed]
  • Golin JE, Esposito MS. Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis in Saccharomyces. Mol Gen Genet. 1977 Jan 18;150(2):127–135. [PubMed]
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