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Proc Natl Acad Sci U S A. Feb 1976; 73(2): 327–330.
PMCID: PMC335900

5'-terminal structure of poliovirus polyribosomal RNA is pUp.

Abstract

Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of poliovirus RNA. We conclude that a 5'-terminal m7G is not required for translation of at least one RNA species in animal cells.

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Selected References

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