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Nucleic Acids Res. May 25, 1991; 19(10): 2539–2566.
PMCID: PMC328170

Organization of restriction-modification systems.


The genes for over 100 restriction-modification systems have now been cloned, and approximately one-half have been sequenced. Despite their similar function, they are exceedingly heterogeneous. The heterogeneity is evident at three levels: in the gene arrangements; in the enzyme compositions; and in the protein sequences. This paper summarizes the main features of the R-M systems that have been cloned.

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