• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of narLink to Publisher's site
Nucleic Acids Res. Apr 24, 1981; 9(8): 1963–1971.
PMCID: PMC326816

Periodicity in DNA primary structure is defined by secondary structure of the coded protein.


A 10.5-base periodicity found earlier is inherent in both eu- and prokaryotic coding nucleotide sequences. In the case of noncoding eukaryotic sequences no periodicity is found, so the 10.5-base oscillation seemingly does not correlate with the nucleosomal organization of DNA. It is shown that the DNA fragments, coding the alpha-helical protein segments, manifest the pronounced 10.5-base periodicity, while those regions of DNA which code the beta-structure have a 6-base oscillation. The repeating pattern of nucleotide sequences can be used for comparison of the DNA segments with low degree of homology.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (631K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ponder BA, Crawford LV. The arrangement of nucleosomes in nucleoprotein complexes from polyoma virus and SV40. Cell. 1977 May;11(1):35–49. [PubMed]
  • Nedospasov SA, Georgiev GP. Non-random cleavage of SV40 DNA in the compact minichromosome and free in solution by micrococcal nuclease. Biochem Biophys Res Commun. 1980 Jan 29;92(2):532–539. [PubMed]
  • Levy A, Noll M. Multiple phases of nucleosomes in the hsp 70 genes of Drosophila melanogaster. Nucleic Acids Res. 1980 Dec 20;8(24):6059–6068. [PMC free article] [PubMed]
  • Trifonov EN, Sussman JL. The pitch of chromatin DNA is reflected in its nucleotide sequence. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3816–3820. [PMC free article] [PubMed]
  • Trifonov EN. Sequence-dependent deformational anisotropy of chromatin DNA. Nucleic Acids Res. 1980 Sep 11;8(17):4041–4053. [PMC free article] [PubMed]
  • Wing R, Drew H, Takano T, Broka C, Tanaka S, Itakura K, Dickerson RE. Crystal structure analysis of a complete turn of B-DNA. Nature. 1980 Oct 23;287(5784):755–758. [PubMed]
  • Zhurkin VB, Lysov YP, Ivanov VI. Anisotropic flexibility of DNA and the nucleosomal structure. Nucleic Acids Res. 1979 Mar;6(3):1081–1096. [PMC free article] [PubMed]
  • Reddy VB, Thimmappaya B, Dhar R, Subramanian KN, Zain BS, Pan J, Ghosh PK, Celma ML, Weissman SM. The genome of simian virus 40. Science. 1978 May 5;200(4341):494–502. [PubMed]
  • Sanger F, Coulson AR, Friedmann T, Air GM, Barrell BG, Brown NL, Fiddes JC, Hutchison CA, 3rd, Slocombe PM, Smith M. The nucleotide sequence of bacteriophage phiX174. J Mol Biol. 1978 Oct 25;125(2):225–246. [PubMed]
  • Schiffer M, Edmundson AB. Use of helical wheels to represent the structures of proteins and to identify segments with helical potential. Biophys J. 1967 Mar;7(2):121–135. [PMC free article] [PubMed]
  • van Ooyen A, van den Berg J, Mantei N, Weissmann C. Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science. 1979 Oct 19;206(4416):337–344. [PubMed]
  • Sack JS, Andrews LC, Magnus KA, Hanson JC, Rubin J, Love WE. Location of amino acid residues in human deoxy hemoglobin. Hemoglobin. 1978;2(2):153–169. [PubMed]
  • Edelman GM. The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications. Biochemistry. 1970 Aug 4;9(16):3197–3205. [PubMed]
  • Poljak RJ, Amzel LM, Phizackerley RP. Studies on the three-dimensional structure of immunoglobulins. Prog Biophys Mol Biol. 1976;31(1):67–93. [PubMed]
  • Schulz GE, Barry CD, Friedman J, Chou PY, Fasman GD, Finkelstein AV, Lim VI, Pititsyn OB, Kabat EA, Wu TT, et al. Comparison of predicted and experimentally determined secondary structure of adenyl kinase. Nature. 1974 Jul 12;250(462):140–142. [PubMed]
  • Hamlyn PH, Browniee GG, Cheng CC, Gait MJ, Milstein C. Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing. Cell. 1978 Nov;15(3):1067–1075. [PubMed]
  • Bernard O, Hozumi N, Tonegawa S. Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell. 1978 Dec;15(4):1133–1144. [PubMed]
  • Schaffner W, Kunz G, Daetwyler H, Telford J, Smith HO, Birnstiel ML. Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing. Cell. 1978 Jul;14(3):655–671. [PubMed]
  • Nussinov R. Some rules in the ordering of nucleotides in the DNA. Nucleic Acids Res. 1980 Oct 10;8(19):4545–4562. [PMC free article] [PubMed]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...