• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of narLink to Publisher's site
Nucleic Acids Res. Jan 11, 1982; 10(1): 421–431.
PMCID: PMC326143

A strategy for sequence phylogeny research.


Minimal mutation trees, and almost minimal trees, are constructed from two data sets, one of phenylalanine tRNA sequences, and the other of 5S RNA sequences, from a diverse range of organisms. The two sets of results are mutually consistent. Trees representing previous evolutionary hypotheses are compared using a total weighted mutational distance criterion. The importance of sequence data from relatively little-studed phylogenetic lines is stressed. A procedure is illustrated which circumvents the computational difficulty of evaluating the astronomically large number of possible trees, without resorting to suboptimal methods.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (732K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Schwartz RM, Dayhoff MO. Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts. Science. 1978 Jan 27;199(4327):395–403. [PubMed]
  • Hori H, Osawa S. Evolutionary change in 5S RNA secondary structure and a phylogenic tree of 54 5S RNA species. Proc Natl Acad Sci U S A. 1979 Jan;76(1):381–385. [PMC free article] [PubMed]
  • Fox GE, Stackebrandt E, Hespell RB, Gibson J, Maniloff J, Dyer TA, Wolfe RS, Balch WE, Tanner RS, Magrum LJ, et al. The phylogeny of prokaryotes. Science. 1980 Jul 25;209(4455):457–463. [PubMed]
  • Küntzel H, Heidrich M, Piechulla B. Phylogenetic tree derived from bacterial, cytosol and organelle 5S rRNA sequences. Nucleic Acids Res. 1981 Mar 25;9(6):1451–1461. [PMC free article] [PubMed]
  • Cedergren RJ, Sankoff D, LaRue B, Grosjean H. The evolving tRNA molecule. CRC Crit Rev Biochem. 1981;11(1):35–104. [PubMed]
  • Erdmann VA. Collection of published 5S and 5.8S RNA sequences and their precursors. Nucleic Acids Res. 1981 Jan 10;9(1):r25–r42. [PMC free article] [PubMed]
  • Simoncsits A. 3' Terminal labelling of RNA of RNA with beta-32P-pyrophosphate group and its application to the sequence analysis of 5S RNA from Streptomyces griseus. Nucleic Acids Res. 1980 Sep 25;8(18):4111–4124. [PMC free article] [PubMed]
  • Sankoff D, Cedergren RJ, Lapalme G. Frequency of insertion-deletion, transversion, and transition in the evolution of 5S ribosomal RNA. J Mol Evol. 1976 Mar 29;7(2):133–149. [PubMed]
  • Larue B, Cedergren RJ, Sankoff D, Grosjean H. Evolution of methionine initiator and phenylalanine transfer RNAs. J Mol Evol. 1979 Dec;14(4):287–300. [PubMed]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...