• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of thijCurrent IssueSee also Cardiovascular Diseases Journal in PMCSubscribeSubmissionsTHI Journal Website
Tex Heart Inst J. 1997; 24(2): 81–89.
PMCID: PMC325409

Chelation therapy for cardiovascular disease. Review and commentary.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.7M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Conti CR. Chelation therapy for atherosclerosis: one man's view. Clin Cardiol. 1995 Oct;18(10):545–545. [PubMed]
  • Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, Delbanco TL. Unconventional medicine in the United States. Prevalence, costs, and patterns of use. N Engl J Med. 1993 Jan 28;328(4):246–252. [PubMed]
  • BESSMAN SP, RIED H, RUBIN M. Treatment of lead encephalopathy with calcium disodium versenate; report of a case. Med Ann Dist Columbia. 1952 Jun;21(6):312–315. [PubMed]
  • RUBIN M, GIGNAC S, BESSMAN SP, BELKNAP EL. Enhancement of lead excretion in humans by disodium calcium ethylene-diamine tetraacetate. Science. 1953 Jun 12;117(3050):659–660. [PubMed]
  • SPENCER H, VANKINSCOTT V, LEWIN I, LASZLO D. Removal of calcium in man by ethylenediamine tetra-acetic acid. A metabolic study. J Clin Invest. 1952 Dec;31(12):1023–1027. [PMC free article] [PubMed]
  • HOLLAND JF, DANIELSON E, SAHAGIAN-EDWARDS A. Use of ethylene diamine tetra acetic acid in hypercalcemic patients. Proc Soc Exp Biol Med. 1953 Nov;84(2):359–364. [PubMed]
  • BELLIN J, LASZLO D. Metabolism and removal of Ca45 in man. Science. 1953 Mar 27;117(3039):331–334. [PubMed]
  • FOREMAN H, FUQUA PA, NORWOOD WD. Experimental administration of ethylenediamine-tetraacetic acid in plutonium poisoning. AMA Arch Ind Health. 1954 Sep;10(3):226–231. [PubMed]
  • Tymianski M, Wallace MC, Spigelman I, Uno M, Carlen PL, Tator CH, Charlton MP. Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo. Neuron. 1993 Aug;11(2):221–235. [PubMed]
  • Tymianski M, Charlton MP, Carlen PL, Tator CH. Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro. J Neurophysiol. 1994 Oct;72(4):1973–1992. [PubMed]
  • SAPEIKA N. Antagonism of digitalis action by ethylenediamine tetraacetic acid. Arch Int Pharmacodyn Ther. 1954 Apr 1;97(3-4):373–378. [PubMed]
  • GUBNER RS, KALLMAN H. Treatment of digitalis toxicity by chelation of serum calcium. Am J Med Sci. 1957 Aug;234(2):136–144. [PubMed]
  • CLARKE NE, CLARKE CN, MOSHER RE. The in vivo dissolution of metastatic calcium; an approach to atherosclerosis. Am J Med Sci. 1955 Feb;229(2):142–149. [PubMed]
  • CLARKE CN, CLARKE NE, MOSHER RE. Treatment of angina pectoris with disodium ethylene diamine tetraacetic acid. Am J Med Sci. 1956 Dec;232(6):654–666. [PubMed]
  • KITCHELL JR, PALMON F, Jr, AYTAN N, MELTZER LE. The treatment of coronary artery disease with disodium EDTA. A reappraisal. Am J Cardiol. 1963 Apr;11:501–506. [PubMed]
  • KITCHELL JR, MELTZER LE, SEVEN MJ. Potential uses of chelation methods in the treatment of cardiovascular diseases. Prog Cardiovasc Dis. 1961 Jan;3:338–349. [PubMed]
  • Guldager B, Jelnes R, Jørgensen SJ, Nielsen JS, Klaerke A, Mogensen K, Larsen KE, Reimer E, Holm J, Ottesen S. EDTA treatment of intermittent claudication--a double-blind, placebo-controlled study. J Intern Med. 1992 Mar;231(3):261–267. [PubMed]
  • CLARKE NE, Sr, CLARKE NE, Jr, MOSHER RE. Treatment of occlusive vascular disease with disodium ethylene diamine tetraacetic acid (EDTA). Am J Med Sci. 1960 Jun;239:732–744. [PubMed]
  • LAMAR CP. CHELATION THERAPY OF OCCLUSIVE ARTERIOSCLEROSIS IN DIABETIC PATIENTS. Angiology. 1964 Sep;15:379–395. [PubMed]
  • Lamar CP. Chelation endarterectomy for occlusive atherosclerosis. J Am Geriatr Soc. 1966 Mar;14(3):272–294. [PubMed]
  • Olszewer E, Carter JP. EDTA chelation therapy in chronic degenerative disease. Med Hypotheses. 1988 Sep;27(1):41–49. [PubMed]
  • Godfrey ME. EDTA chelation as a treatment of arteriosclerosis. N Z Med J. 1990 Apr 11;103(887):162–163. [PubMed]
  • Grier MT, Meyers DG. So much writing, so little science: a review of 37 years of literature on edetate sodium chelation therapy. Ann Pharmacother. 1993 Dec;27(12):1504–1509. [PubMed]
  • Ornish D. Can lifestyle changes reverse coronary heart disease? World Rev Nutr Diet. 1993;72:38–48. [PubMed]
  • Ornish D, Scherwitz LW, Doody RS, Kesten D, McLanahan SM, Brown SE, DePuey E, Sonnemaker R, Haynes C, Lester J, et al. Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA. 1983 Jan 7;249(1):54–59. [PubMed]
  • Wynn JE, Van't Riet B, Borzelleca JF. The toxicity and pharmacodynamics of EGTA: oral administration to rats and comparisons with EDTA. Toxicol Appl Pharmacol. 1970 May;16(3):807–817. [PubMed]
  • PAGE IH. Atherosclerosis; an introduction. Circulation. 1954 Jul;10(1):1–27. [PubMed]
  • Allain P, Mauras Y, Premel-Cabic A, Islam S, Herve JP, Cledes J. Effects of an EDTA infusion on the urinary elimination of several elements in healthy subjects. Br J Clin Pharmacol. 1991 Mar;31(3):347–349. [PMC free article] [PubMed]
  • Monaco GP, Green S. Recognizing deception in the promotion of untested and unproven medical treatments. N Y State J Med. 1993 Feb;93(2):88–91. [PubMed]
  • Holohan TV. Referral by default. The medical community and unorthodox therapy. JAMA. 1987 Mar 27;257(12):1641–1642. [PubMed]
  • Murray RH, Rubel AJ. Physicians and healers--unwitting partners in health care. N Engl J Med. 1992 Jan 2;326(1):61–64. [PubMed]
  • Cole D, St George I. Medicine at the fringes. N Z Med J. 1993 Apr 14;106(953):130–133. [PubMed]

Articles from Texas Heart Institute Journal are provided here courtesy of Texas Heart Institute

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...