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PMC full text:
J Neuroimmunol. Author manuscript; available in PMC 2012 Dec 15.
Published in final edited form as:
J Neuroimmunol. 2011 Dec 15; 240-241: 65–73.
Published online 2011 Nov 17. doi:  10.1016/j.jneuroim.2011.10.010

Figure 7

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Adoptive transfer of GM-CSF expanded Tregs (exposed and not exposed to AChR)

Recipient mice were immunized and boosted with tAChR and divided into two treatment groups. Mice were adoptively transferred with Tregs (CD4+ CD25+ cells) from GM-CSF-treated EAMG donors (solid circles) or Tregs from GM-CSF-treated mice not exposed to AChR (solid squares). A. Serial determinations of mean clinical score are shown with day 0 corresponding to the day of adoptive transfer. B. Anti-AChR antibodies were determined using an ELISA assay at baseline (before adoptive transfer), prior to the tAChR boost (arrow) 30 days after adoptive transfer (After), and at the end of the study (post-boost). Mean OD values and standard errors are shown for three separate experiments. In each case, the post-treatment values were compared to the baseline value to determine significance (p < 0.05). *Statistically significant value (p < 0.05).

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