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Proc Natl Acad Sci U S A. Feb 1981; 78(2): 1095–1099.
PMCID: PMC319953

Engrailed: a gene controlling compartment and segment formation in Drosophila.


A total of 58 mutations at the engrailed locus were isolated. Analysis suggests that this genetic locus is necessary for survival but required only in the cells of the posterior compartments. Inactivation of the engrailed locus renders the animal incapable of maintaining the separation between the groups of cells that constitute either the compartments that subdivide each segment or the individual segments themselves.

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Selected References

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  • Lawrence PA. A clonal analysis of segment development in Oncopeltus (Hemiptera). J Embryol Exp Morphol. 1973 Dec;30(3):681–699. [PubMed]
  • Garcia-Bellido A, Ripoll P, Morata G. Developmental compartmentalisation of the wing disk of Drosophila. Nat New Biol. 1973 Oct 24;245(147):251–253. [PubMed]
  • Garcia-Bellido A, Ripoll P, Morata G. Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila. Dev Biol. 1976 Jan;48(1):132–147. [PubMed]
  • Brasted A. An Analysis of the Expression of the Mutant "Engrailed" in Drosophila Melanogaster. Genetics. 1941 May;26(3):347–373. [PMC free article] [PubMed]
  • TOKUNAGA C. The differentiation of a secondary sex comb under the influence of the gene engrailed in Drosophila melanogaster. Genetics. 1961 Feb;46:157–176. [PMC free article] [PubMed]
  • Garcia-Bellido A, Santamaria P. Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster. Genetics. 1972 Sep;72(1):87–104. [PMC free article] [PubMed]
  • Lawrence PA, Morata G. Compartments in the wing of Drosophila: a study of the engrailed gene. Dev Biol. 1976 Jun;50(2):321–337. [PubMed]
  • García-Bellido A. Genetic control of wing disc development in Drosophila. Ciba Found Symp. 1975;0(29):161–182. [PubMed]
  • Garcia-Bellido A, Dapena J. Induction, detection and characterization of cell differentiation mutants in Drosophila. Mol Gen Genet. 1974;128(2):117–130. [PubMed]
  • Morata G, Ripoll P. Minutes: mutants of drosophila autonomously affecting cell division rate. Dev Biol. 1975 Feb;42(2):211–221. [PubMed]
  • Zalokar M, Erk I. Phase-partition fixation and staining of Drosophila eggs. Stain Technol. 1977 Mar;52(2):89–95. [PubMed]
  • Lindsley DL, Sandler L, Baker BS, Carpenter AT, Denell RE, Hall JC, Jacobs PA, Miklos GL, Davis BK, Gethmann RC, et al. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. [PMC free article] [PubMed]
  • Morata G, Lawrence PA. Development of the eye-antenna imaginal disc of Drosophila. Dev Biol. 1979 Jun;70(2):355–371. [PubMed]
  • Wieschaus E, Gehring W. Clonal analysis of primordial disc cells in the early embryo of Drosophila melanogaster. Dev Biol. 1976 Jun;50(2):249–263. [PubMed]
  • Szabad J, Schüpbach T, Wieschaus E. Cell lineage and development in the larval epidermis of Drosophila melanogaster. Dev Biol. 1979 Dec;73(2):256–271. [PubMed]
  • Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 1980 Oct 30;287(5785):795–801. [PubMed]

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