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Proc Natl Acad Sci U S A. 1987 February; 84(4): 1123–1126. | PMCID: PMC304375 |
Peripheral nerve injury in developing rats reorganizes representation pattern in motor cortex. J P Donoghue and J N Sanes Abstract We investigated the effect of neonatal nerve lesions on cerebral motor cortex organization by comparing the cortical motor representation of normal adult rats with adult rats that had one forelimb removed on the day of birth. Mapping of cerebral neocortex with electrical stimulation revealed an altered relationship between the motor cortex and the remaining muscles. Whereas distal forelimb movements are normally elicited at the lowest threshold in the motor cortex forelimb area, the same stimuli activated shoulder and trunk muscles in experimental animals. In addition, an expanded cortical representation of intact body parts was present and there was an absence of a distinct portion of motor cortex. These data demonstrate that representation patterns in motor cortex can be altered by peripheral nerve injury during development. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (843K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Kaas JH, Merzenich MM, Killackey HP. The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals. Annu Rev Neurosci. 1983;6:325–356. [PubMed]
- Merzenich MM, Kaas JH, Wall J, Nelson RJ, Sur M, Felleman D. Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation. Neuroscience. 1983 Jan;8(1):33–55. [PubMed]
- Merzenich MM, Kaas JH, Wall JT, Sur M, Nelson RJ, Felleman DJ. Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys. Neuroscience. 1983 Nov;10(3):639–665. [PubMed]
- Wiesel TN, Hubel DH. Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. J Neurophysiol. 1965 Nov;28(6):1029–1040. [PubMed]
- Shatz CJ, Stryker MP. Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation. J Physiol. 1978 Aug;281:267–283. [PubMed]
- Hubel DH, Wiesel TN, LeVay S. Plasticity of ocular dominance columns in monkey striate cortex. Philos Trans R Soc Lond B Biol Sci. 1977 Apr 26;278(961):377–409. [PubMed]
- Ivy GO, Killackey HP. The ontogeny of the distribution of callosal projection neurons in the rat parietal cortex. J Comp Neurol. 1981 Jan 20;195(3):367–389. [PubMed]
- Ivy GO, Killackey HP. Ontogenetic changes in the projections of neocortical neurons. J Neurosci. 1982 Jun;2(6):735–743. [PubMed]
- Innocenti GM, Frost DO. The postnatal development of visual callosal connections in the absence of visual experience or of the eyes. Exp Brain Res. 1980;39(4):365–375. [PubMed]
- Stoney SD, Jr, Thompson WD, Asanuma H. Excitation of pyramidal tract cells by intracortical microstimulation: effective extent of stimulating current. J Neurophysiol. 1968 Sep;31(5):659–669. [PubMed]
- Humphrey DR, Reed DJ. Separate cortical systems for control of joint movement and joint stiffness: reciprocal activation and coactivation of antagonist muscles. Adv Neurol. 1983;39:347–372. [PubMed]
- Donoghue JP, Wise SP. The motor cortex of the rat: cytoarchitecture and microstimulation mapping. J Comp Neurol. 1982 Nov 20;212(1):76–88. [PubMed]
- Sanderson KJ, Welker W, Shambes GM. Reevaluation of motor cortex and of sensorimotor overlap in cerebral cortex of albino rats. Brain Res. 1984 Feb 6;292(2):251–260. [PubMed]
- Donoghue JP, Kerman KL, Ebner FF. Evidence for two organizational plans within the somatic sensory-motor cortex of the rat. J Comp Neurol. 1979 Feb 1;183(3):647–663. [PubMed]
- Donoghue JP, Parham C. Afferent connections of the lateral agranular field of the rat motor cortex. J Comp Neurol. 1983 Jul 10;217(4):390–404. [PubMed]
- Neafsey EJ, Sievert C. A second forelimb motor area exists in rat frontal cortex. Brain Res. 1982 Jan 28;232(1):151–156. [PubMed]
- Easter SS, Jr, Purves D, Rakic P, Spitzer NC. The changing view of neural specificity. Science. 1985 Nov 1;230(4725):507–511. [PubMed]
- Innocenti GM, Frost DO. Effects of visual experience on the maturation of the efferent system to the corpus callosum. Nature. 1979 Jul 19;280(5719):231–234. [PubMed]
- Cabana T, Martin GF. Corticospinal development in the North-American opossum: evidence for a sequence in the growth of cortical axons in the spinal cord and for transient projections. Brain Res. 1985 Nov;355(1):69–80. [PubMed]
- O'Leary DD, Stanfield BB, Cowan WM. Evidence that the early postnatal restriction of the cells of origin of the callosal projection is due to the elimination of axonal collaterals rather than to the death of neurons. Brain Res. 1981 Jul;227(4):607–617. [PubMed]
- Donoghue JP. Contrasting properties of neurons in two parts of the primary motor cortex of the awake rat. Brain Res. 1985 Apr 29;333(1):173–177. [PubMed]
- Devor M, Wall PD. Reorganisation of spinal cord sensory map after peripheral nerve injury. Nature. 1978 Nov 2;276(5683):75–76. [PubMed]
- Devor M, Wall PD. Effect of peripheral nerve injury on receptive fields of cells in the cat spinal cord. J Comp Neurol. 1981 Jun 20;199(2):277–291. [PubMed]
- Sica RE, Sanz OP, Cohen LG, Freyre JD, Panizza M. Changes in the N1-P1 component of the somatosensory cortical evoked response in patients with partial limb amputation. Electromyogr Clin Neurophysiol. 1984 Jun–Jul;24(5):415–427. [PubMed]
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