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J Clin Invest. 1972 April; 51(4): 848–867. doi: 10.1172/JCI106880. | PMCID: PMC302199 |
Study of Four New Kindreds with Inherited Thyroxine-Binding Globulin Abnormalities POSSIBLE MUTATIONS OF A SINGLE GENE LOCUS Samuel Refetoff, Noel I. Robin, and Chester A. Alper Thyroid Study Unit, University of Chicago, School of Medicine, Chicago, Illinois 60637 Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115 Abstract Five families with inherited thyroxine-binding globulin (TBG) abnormalities were studied. On the basis of serum thyroxine (T4)- binding capacity of TBG in affected males, three family types were identified: TBG deficiency, low TBG, and high TBG capacity. In all families evidence for X-linked inheritance was obtained and in one family all criteria establishing this mode of inheritance were met. Only females were heterozygous, exhibiting values intermediate between affected males and normals. Overlap in heterozygotes was most commonly encountered in families with low TBG. Quantitative variation in the serum concentration of functionally normal TBG was demonstrated by: (a) failure of serum from TBG-deficient subjects to react with anti-TBG antibodies; (b) normal kinetics of T4 and triiodothyronine-binding to TBG in sera from subjects with low TBG and high TBG capacity; (c) concordance of estimates of TBG concentration by T4 saturation and by immunological methods; and (d) normal rate of heat inactivation of TBG. No abnormalities in serum transport of cortisol, testosterone, aldosterone, or thyroxine bound to prealbumin could be detected. These observations suggest that all the TBG abnormalities thus far observed reflect mutations at a single X-linked locus involved in the control of TBG synthesis. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - BEIERWALTES WH, ROBBINS J. Familial increase in the thyroxine-binding sites in serum alpha globulin. J Clin Invest. 1959 Oct;38:1683–1688. [PubMed]
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