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Bioinformatics. Jan 15, 2011; 27(2): 272–274.
Published online Nov 12, 2010. doi:  10.1093/bioinformatics/btq640
PMCID: PMC3018812

The uniqueome: a mappability resource for short-tag sequencing

Abstract

Summary: Quantification applications of short-tag sequencing data (such as CNVseq and RNAseq) depend on knowing the uniqueness of specific genomic regions at a given threshold of error. Here, we present the ‘uniqueome’, a genomic resource for understanding the uniquely mappable proportion of genomic sequences. Pre-computed data are available for human, mouse, fly and worm genomes in both color-space and nucletotide-space, and we demonstrate the utility of this resource as applied to the quantification of RNAseq data.

Availability: Files, scripts and supplementary data are available from http://grimmond.imb.uq.edu.au/uniqueome/; the ISAS uniqueome aligner is freely available from http://www.imagenix.com/.

Contact: ua.ude.qu@nanoolc.n

Supplementary information: Supplementary data are available at Bioinformatics online.


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