• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. Nov 1987; 84(21): 7524–7528.
PMCID: PMC299331

Spin glasses and the statistical mechanics of protein folding.

Abstract

The theory of spin glasses was used to study a simple model of protein folding. The phase diagram of the model was calculated, and the results of dynamics calculations are briefly reported. The relation of these results to folding experiments, the relation of these hypotheses to previous protein folding theories, and the implication of these hypotheses for protein folding prediction schemes are discussed.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (930K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Anfinsen CB. Principles that govern the folding of protein chains. Science. 1973 Jul 20;181(4096):223–230. [PubMed]
  • Kim PS, Baldwin RL. Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding. Annu Rev Biochem. 1982;51:459–489. [PubMed]
  • Paine GH, Scheraga HA. Prediction of the native conformation of a polypeptide by a statistical-mechanical procedure. I. Backbone structure of enkephalin. Biopolymers. 1985 Aug;24(8):1391–1436. [PubMed]
  • Weber G. Phenomenological description of the association of protein subunits subjected to conformational drift. Effects of dilution and of hydrostatic pressure. Biochemistry. 1986 Jun 17;25(12):3626–3631. [PubMed]
  • King L, Weber G. Conformational drift of dissociated lactate dehydrogenases. Biochemistry. 1986 Jun 17;25(12):3632–3637. [PubMed]
  • King L, Weber G. Conformational drift and cryoinactivation of lactate dehydrogenase. Biochemistry. 1986 Jun 17;25(12):3637–3640. [PubMed]
  • Silva JL, Miles EW, Weber G. Pressure dissociation and conformational drift of the beta dimer of tryptophan synthase. Biochemistry. 1986 Sep 23;25(19):5780–5786. [PubMed]
  • Xu G, Weber G. Dynamics and time-averaged chemical potential of proteins: importance in oligomer association. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5268–5271. [PMC free article] [PubMed]
  • Stein DL. A model of protein conformational substates. Proc Natl Acad Sci U S A. 1985 Jun;82(11):3670–3672. [PMC free article] [PubMed]
  • Ansari A, Berendzen J, Bowne SF, Frauenfelder H, Iben IE, Sauke TB, Shyamsunder E, Young RD. Protein states and proteinquakes. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5000–5004. [PMC free article] [PubMed]
  • Dolgikh DA, Gilmanshin RI, Brazhnikov EV, Bychkova VE, Semisotnov GV, Venyaminov SYu, Ptitsyn OB. Alpha-Lactalbumin: compact state with fluctuating tertiary structure? FEBS Lett. 1981 Dec 28;136(2):311–315. [PubMed]
  • Ohgushi M, Wada A. 'Molten-globule state': a compact form of globular proteins with mobile side-chains. FEBS Lett. 1983 Nov 28;164(1):21–24. [PubMed]
  • Wetlaufer DB. Nucleation, rapid folding, and globular intrachain regions in proteins. Proc Natl Acad Sci U S A. 1973 Mar;70(3):697–701. [PMC free article] [PubMed]
  • Karplus M, Weaver DL. Protein-folding dynamics. Nature. 1976 Apr 1;260(5550):404–406. [PubMed]
  • Scheraga HA. Recent progress in the theoretical treatment of protein folding. Biopolymers. 1983 Jan;22(1):1–14. [PubMed]
  • Kirkpatrick S, Gelatt CD, Jr, Vecchi MP. Optimization by simulated annealing. Science. 1983 May 13;220(4598):671–680. [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...