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Proc Natl Acad Sci U S A. Dec 1989; 86(24): 9941–9945.
PMCID: PMC298618

An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis.

Abstract

We have isolated and molecularly cloned a highly pathogenic virus variant, J3V1, from murine plasmacytomas induced by a combination of pristane and the weakly transforming recombinant retrovirus J3. J3 virus is a derivative of the v-raf/v-myc-carrying J2 virus that was generated by a frameshifting deletion inactivating v-raf in J2. J3V1 contains an additional deletion of 334 base paris in gag, which restores the correct reading frame for v-raf and results in the expression of a p57 gag-raf fusion protein. Reactivation of v-raf in J3 is required for efficient plasmacytoma acceleration in pristane-conditioned BALB/cAn mice.

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Selected References

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  • Potter M. Plasmacytomas in mice. Semin Oncol. 1986 Sep;13(3):275–281. [PubMed]
  • Sümegi J, Spira J, Bazin H, Szpirer J, Levan G, Klein G. Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Nature. 1983 Dec 1;306(5942):497–498. [PubMed]
  • Potter M, Mushinski JF, Mushinski EB, Brust S, Wax JS, Wiener F, Babonits M, Rapp UR, Morse HC., 3rd Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis. Science. 1987 Feb 13;235(4790):787–789. [PubMed]
  • Rapp UR, Cleveland JL, Fredrickson TN, Holmes KL, Morse HC, 3rd, Jansen HW, Patschinsky T, Bister K. Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol. 1985 Jul;55(1):23–33. [PMC free article] [PubMed]
  • Troppmair J, Huleihel M, Cleveland J, Mushinski JF, Kurie J, Morse HC, 3rd, Wax JS, Potter M, Rapp UR. Plasmacytoma induction by J series of v-myc recombinant retroviruses: evidence for the requirement of two (raf and myc) oncogenes for transformation. Curr Top Microbiol Immunol. 1988;141:110–114. [PubMed]
  • Morse HC, 3rd, Hartley JW, Fredrickson TN, Yetter RA, Majumdar C, Cleveland JL, Rapp UR. Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6868–6872. [PMC free article] [PubMed]
  • Clynes R, Wax J, Stanton LW, Smith-Gill S, Potter M, Marcu KB. Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6067–6071. [PMC free article] [PubMed]
  • Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH, Jr, Stephenson JR. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4218–4222. [PMC free article] [PubMed]
  • Rapp UR, Reynolds FH, Jr, Stephenson JR. New mammalian transforming retrovirus: demonstration of a polyprotein gene product. J Virol. 1983 Mar;45(3):914–924. [PMC free article] [PubMed]
  • Stern DF, Roberts AB, Roche NS, Sporn MB, Weinberg RA. Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor. Mol Cell Biol. 1986 Mar;6(3):870–877. [PMC free article] [PubMed]
  • Schultz AM, Copeland T, Oroszlan S, Rapp UR. Identification and characterization of c-raf phosphoproteins in transformed murine cells. Oncogene. 1988 Feb;2(2):187–193. [PubMed]
  • Cleveland JL, Huleihel M, Bressler P, Siebenlist U, Akiyama L, Eisenman RN, Rapp UR. Negative regulation of c-myc transcription involves myc family proteins. Oncogene Res. 1988;3(4):357–375. [PubMed]
  • Ohno S, Migita S, Wiener F, Babonits M, Klein G, Mushinski JF, Potter M. Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus. J Exp Med. 1984 Jun 1;159(6):1762–1777. [PMC free article] [PubMed]
  • Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985 Dec 12;318(6046):533–538. [PubMed]
  • van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T, Berns A. Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell. 1989 Feb 24;56(4):673–682. [PubMed]
  • Rapp UR, Heidecker G, Huleihel M, Cleveland JL, Choi WC, Pawson T, Ihle JN, Anderson WB. raf family serine/threonine protein kinases in mitogen signal transduction. Cold Spring Harb Symp Quant Biol. 1988;53(Pt 1):173–184. [PubMed]
  • Huleihel M, Goldsborough M, Cleveland J, Gunnell M, Bonner T, Rapp UR. Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Mol Cell Biol. 1986 Jul;6(7):2655–2662. [PMC free article] [PubMed]
  • Principato M, Klinken SP, Cleveland JL, Rapp UR, Holmes KL, Pierce JH, Morse HC., 3rd In vitro transformation of murine bone marrow cells with a v-raf/v-myc retrovirus yields clonally related mature B cells and macrophages. Curr Top Microbiol Immunol. 1988;141:31–41. [PubMed]

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