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Proc Natl Acad Sci U S A. 1989 Jul; 86(14): 5459–5463.
PMCID: PMC297642

Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.


Antennapedia-class vertebrate homeobox genes have been classified with regard to their chromosomal locations and nucleotide sequence similarities within the 183-base-pair homeobox domain. The results of these comparisons support the view that in mammals and most likely the vertebrates, four clusters of homeobox genes exist that were created by duplications of an entire primordial gene cluster. We present evidence that this primordial cluster arose by local gene duplications of homeoboxes that were present before the divergence of arthropods and chordates. Sequence analyses indicate that the expansion of the primordial gene cluster complex was accompanied by diversification, whereas conservation predominated after the duplications of entire homeobox gene clusters.

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Selected References

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  • Gehring WJ. Homeo boxes in the study of development. Science. 1987 Jun 5;236(4806):1245–1252. [PubMed]
  • Ingham PW. The molecular genetics of embryonic pattern formation in Drosophila. Nature. 1988 Sep 1;335(6185):25–34. [PubMed]
  • Boncinelli E, Somma R, Acampora D, Pannese M, D'Esposito M, Faiella A, Simeone A. Organization of human homeobox genes. Hum Reprod. 1988 Oct;3(7):880–886. [PubMed]
  • Fritz A, De Robertis EM. Xenopus homeobox-containing cDNAs expressed in early development. Nucleic Acids Res. 1988 Feb 25;16(4):1453–1469. [PMC free article] [PubMed]
  • Harvey RP, Tabin CJ, Melton DA. Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products. EMBO J. 1986 Jun;5(6):1237–1244. [PMC free article] [PubMed]
  • Fjose A, Molven A, Eiken HG. Molecular cloning and characterization of homeo-box-containing genes from Atlantic salmon. Gene. 1988;62(1):141–152. [PubMed]
  • Jukes TH, King JL. Evolutionary nucleotide replacements in DNA. Nature. 1979 Oct 18;281(5732):605–606. [PubMed]
  • Regulski M, Harding K, Kostriken R, Karch F, Levine M, McGinnis W. Homeo box genes of the Antennapedia and bithorax complexes of Drosophila. Cell. 1985 Nov;43(1):71–80. [PubMed]
  • Kuroiwa A, Kloter U, Baumgartner P, Gehring WJ. Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts. EMBO J. 1985 Dec 30;4(13B):3757–3764. [PMC free article] [PubMed]
  • Fritz AF, Cho KW, Wright CV, Jegalian BG, De Robertis EM. Duplicated homeobox genes in Xenopus. Dev Biol. 1989 Feb;131(2):584–588. [PubMed]
  • Do MS, Lonai P. Gene organization of murine homeobox-containing gene clusters. Genomics. 1988 Oct;3(3):195–200. [PubMed]
  • Graham A, Papalopulu N, Lorimer J, McVey JH, Tuddenham EG, Krumlauf R. Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes Dev. 1988 Nov;2(11):1424–1438. [PubMed]
  • Baron A, Featherstone MS, Hill RE, Hall A, Galliot B, Duboule D. Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex. EMBO J. 1987 Oct;6(10):2977–2986. [PMC free article] [PubMed]
  • Hoey T, Doyle HJ, Harding K, Wedeen C, Levine M. Homeo box gene expression in anterior and posterior regions of the Drosophila embryo. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4809–4813. [PMC free article] [PubMed]
  • Gehring WJ, Hiromi Y. Homeotic genes and the homeobox. Annu Rev Genet. 1986;20:147–173. [PubMed]
  • Regulski M, McGinnis N, Chadwick R, McGinnis W. Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development. EMBO J. 1987 Mar;6(3):767–777. [PMC free article] [PubMed]

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