• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jcinvestThe Journal of Clinical InvestigationCurrent IssueArchiveSubscriptionAbout the Journal
J Clin Invest. Sep 1968; 47(9): 2143–2151.
PMCID: PMC297375

The regulation of antidiuretic hormone release in man

I. Effects of change in position and ambient temperature on blood ADH levels

Abstract

It has been postulated that alterations in the intravascular distribution of blood affect antidiuretic hormone (ADH) secretion in man. The studies reported here were designed to alter blood distribution by thermal and by positional change to test this thesis.

Human blood ADH levels have been shown to vary with position: a mean value of 0.4 ± 0.6 (SD) μU/ml was obtained while the subject was supine, a value of 1.4 ± 0.7 μU/ml while sitting, and 3.1 ± 1.5 μU/ml while standing. In 79 control subjects, sitting comfortably for 30 min in a normal environment, a blood ADH level of 1.65 ± 0.63 μU/ml was found. It is suggested that subjects assume this position during experiments in which blood is drawn for measurement of ADH levels.

In eight seated subjects the ADH level rose from 1.6 ± 0.4 to 5.2 ± 0.8 μU/ml after a 2 hr exposure at 50°C and fell to 1.0 ± 0.26 μU/ml within 15 min at 26°C.

Six subjects with a mean ADH level of 2.2 ± 0.58 μU/ml sat quietly in the cold (13°C) for 1 hr, and the ADH level fell to 1.2 ± 0.36 μU/ml. After 15 min at 26°C, the level rose to 3.1 ± 0.78 μU/ml. The serum sodium and osmolal concentrations remained constant during all studies.

Water, sodium, and total solute excretion decreased during exposure to the heat, whereas the urine to plasma (U/P) osmolal ratio increased. During cold exposure, water, sodium, and total solute excretion increased, and there was a decrease in the U/P osmolal ratio.

These data are interpreted as indicating that changes in activity of intrathoracic stretch receptors, in response to redistribution of blood, alter ADH secretion independently of changes in serum osmolality. The rapidity of change of blood ADH concentration indicates a great sensitivity and a prime functional role for the “volume receptors” in the regulation of ADH secretion.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • VERNEY EB. The antidiuretic hormone and the factors which determine its release. Proc R Soc Lond B Biol Sci. 1947 Dec 16;135(878):25–106. [PubMed]
  • Aubry RH, Nankin HR, Moses AM, Streeten DH. Measurement of the osmotic threshold for vasopressin release in human subjects, and its modification by cortisol. J Clin Endocrinol Metab. 1965 Nov;25(11):1481–1492. [PubMed]
  • CROSS BA, GREEN JD. Activity of single neurones in the hypothalamus: effect of osmotic and other stimuli. J Physiol. 1959 Oct;148:554–569. [PMC free article] [PubMed]
  • HENRY JP, GAUER OH, REEVES JL. Evidence of the atrial location of receptors influencing urine flow. Circ Res. 1956 Jan;4(1):85–90. [PubMed]
  • GAUER OH, HENRY JP. Circulatory basis of fluid volume control. Physiol Rev. 1963 Jul;43:423–481. [PubMed]
  • HENRY JP, PEARCE JW. The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow. J Physiol. 1956 Mar 28;131(3):572–585. [PMC free article] [PubMed]
  • WEINSTEIN H, BERNE RM, SACHS H. Vasopressin in blood: effect of hemorrhage. Endocrinology. 1960 May;66:712–718. [PubMed]
  • SHARE L. Acute reduction in extracellular fluid volume and the concentration of antidiuretic hormone in blood. Endocrinology. 1961 Nov;69:925–933. [PubMed]
  • YOSHIDA S, MOTOHASHI K, IBAYASHI H, OKINAKA S. METHOD FOR THE ASSAY OF ANTIDIURETIC HORMONE IN PLASMA WITH A NOTE ON THE ANTIDIURETIC TITER OF HUMAN PLASMA. J Lab Clin Med. 1963 Aug;62:279–285. [PubMed]
  • Rogge JD, Moore WW, Segar WE, Fasola AF. Effect of +Gz and +Gx acceleration on peripheral venous ADH levels in humans. J Appl Physiol. 1967 Dec;23(6):870–874. [PubMed]
  • SHARE L. Vascular volume and blood level of antidiuretic hormone. Am J Physiol. 1962 Apr;202:791–794. [PubMed]
  • Rothe CF, Johnson JA, Moore WW. Continuous measurement of conductivity of biological fluids. J Appl Physiol. 1967 Dec;23(6):1010–1013. [PubMed]
  • Share L. Vasopressin, its bioassay and the physiological control of its release. Am J Med. 1967 May;42(5):701–712. [PubMed]
  • Drury DR, Henry JP, Goodman J. THE EFFECTS OF CONTINUOUS PRESSURE BREATHING ON KIDNEY FUNCTION. J Clin Invest. 1947 Sep;26(5):945–951. [PMC free article] [PubMed]
  • GAUER OH, HENRY JP, SIEKER HO, WENDT WE. The effect of negative pressure breathing on urine flow. J Clin Invest. 1954 Feb;33(2):287–296. [PMC free article] [PubMed]
  • SHARE L. EFFECTS OF CAROTID OCCLUSION AND LEFT ATRIAL DISTENTION ON PLASMA VASOPRESSIN TITER. Am J Physiol. 1965 Feb;208:219–223. [PubMed]
  • Shu'ayb WA, Moran WH, Jr, Zimmermann B. Studies of the mechanism of antidiuretic hormone secretion and the post-commissurotomy dilutional syndrome. Ann Surg. 1965 Oct;162(4):690–701. [PMC free article] [PubMed]
  • SHARE L, LEVY MN. Cardiovascular receptors and blood titer of antidiuretic hormone. Am J Physiol. 1962 Sep;203:425–428. [PubMed]
  • SJOSTRAND T. The significance of the pulmonary blood volume in the regulation of the blood circulation under normal and pathological conditions. Acta Med Scand. 1953;145(3):155–168. [PubMed]
  • EPSTEIN FH, GOODYER AVN, LAWRASON FD, RELMAN AS. Studies of the antidiuresis of quiet standing: the importance of changes in plasma volume and glomerular filtration rate. J Clin Invest. 1951 Jan;30(1):63–72. [PMC free article] [PubMed]
  • BADER RA, ELIOT JW, BASS DE. Hormonal and renal mechanisms of cold diuresis. J Appl Physiol. 1952 Feb;4(8):649–658. [PubMed]
  • Lauson HD. Metabolism of antidiuretic hormones. Am J Med. 1967 May;42(5):713–744. [PubMed]
  • LEAF A, BARTTER FC, SANTOS RF, WRONG O. Evidence in man that urinary electrolyte loss induced by pitressin is a function of water retention. J Clin Invest. 1953 Sep;32(9):868–878. [PMC free article] [PubMed]
  • Johnston CI, Davis JO, Howards SS, Wright FS. Cross-circulation experiments on the mechanism of the natriuresis during saline loading in the dog. Circ Res. 1967 Jan;20(1):1–10. [PubMed]
  • DE WARDENER HE, MILLS IH, CLAPHAM WF, HAYTER CJ. Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin Sci. 1961 Oct;21:249–258. [PubMed]
  • Cirksena WJ, Dirks JH, Berliner RW. Effect of thoracic cava obstruction on response of proximal tubule sodium reabsorption to saline infusion. J Clin Invest. 1966 Feb;45(2):179–186. [PMC free article] [PubMed]
  • Bartter FC, Schwartz WB. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967 May;42(5):790–806. [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...