• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jcinvestThe Journal of Clinical InvestigationCurrent IssueArchiveSubscriptionAbout the Journal
J Clin Invest. May 1966; 45(5): 645–657.
PMCID: PMC292742

Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • JANDL JH. The anemia of liver disease: observations on its mechanism. J Clin Invest. 1955 Mar;34(3):390–404. [PMC free article] [PubMed]
  • CASSERD F, FINCH CA, GIBLETT ER, HOUGHTON B, MOTULSKY AG. Studies on the pathogenesis of splenic anemia. Blood. 1956 Dec;11(12):1118–1131. [PubMed]
  • MOTULSKY AG, CASSERD F, GIBLETT ER, BROUN GO, Jr, FINCH CA. Anemia and the spleen. N Engl J Med. 1958 Dec 11;259(24):1164–contd. [PubMed]
  • HARRIS IM, McALISTER J, PRANKERD TA. Splenomegaly and the circulating red cell. Br J Haematol. 1958 Jan;4(1):97–102. [PubMed]
  • HEILMEYER L. Rapports physiologiques entre la rate et la moelle osseuse. Rev Hematol. 1954;9(3):267–290. [PubMed]
  • DAMESHEK W. Hypersplenism. Bull N Y Acad Med. 1955 Feb;31(2):113–136. [PMC free article] [PubMed]
  • WRIGHT CS, DOAN CA, BOURONCLE BA, ZOLLINGER RM. Direct splenic arterial and venous blood studies in the hypersplenic syndromes before and after epinephrine. Blood. 1951 Mar;6(3):195–212. [PubMed]
  • ASTER RH, JANDL JH. PLATELET SEQUESTRATION IN MAN. I. METHODS. J Clin Invest. 1964 May;43:843–855. [PMC free article] [PubMed]
  • Aster RH. Effect of anticoagulant and ABO incompatibility on recovery of transfused human platelets. Blood. 1965 Dec;26(6):732–743. [PubMed]
  • COHEN P, GARDNER FH, BARNETT GO. Reclassification of the thrombocytopenias by the Cr51-labeling method for measuring platelet life span. N Engl J Med. 1961 Jun 22;264:1294–contd. [PubMed]
  • JANDL JH, GREENBERG MS, YONEMOTO RH, CASTLE WB. Clinical determination of the sites of red cell sequestration in hemolytic anemias. J Clin Invest. 1956 Aug;35(8):842–867. [PMC free article] [PubMed]
  • ASTER RH, JANDL JH. PLATELET SEQUESTRATION IN MAN. II. IMMUNOLOGICAL AND CLINICAL STUDIES. J Clin Invest. 1964 May;43:856–869. [PMC free article] [PubMed]
  • JONES NC, MOLLISON PL, VEALL N. Removal of incompatible red cells by the spleen. Br J Haematol. 1957 Apr;3(2):125–133. [PubMed]
  • HEIDELBERG JG, SIROTA PG, DEWEY WC, ROSE RG. DETERMINATION OF THE DISTRIBUTION OF P32 IN PHANTOMS AND IN PATIENTS BY DETECTION OF BREMSSTRAHLUNG RADIATION WITH A SCINTISCANNER. Am J Roentgenol Radium Ther Nucl Med. 1963 Aug;90:325–335. [PubMed]
  • WOLF R, FISCHER J. [Studies on a phantom for use with Cr51 in the problem of the evaluation of organ activity measurements]. Strahlentherapie. 1962 Oct;119:226–235. [PubMed]
  • BRECHER G, CRONKITE EP. Morphology and enumeration of human blood platelets. J Appl Physiol. 1950 Dec;3(6):365–377. [PubMed]
  • CROSBY WH. Normal functions of the spleen relative to red blood cells: a review. Blood. 1959 Apr;14(4):399–408. [PubMed]
  • ROTHSCHILD MA, BAUMAN A, YALOW RS, BERSON SA. Effect of splenomegaly on blood volume. J Appl Physiol. 1954 May;6(11):701–706. [PubMed]
  • FUDENBERG H, BALDINI M, MAHONEY JP, DAMESHEK W. The body hematocrit/venous hematocrit ratio and the "splenic reservoir". Blood. 1961 Jan;17:71–82. [PubMed]
  • TIZIANELLO A, PANNACCIULLI I. The effect of splenomegaly on dilution curves of tagged erythrocytes and red blood cell volume. Coparative studies on normal, anaemic and splenomegalic patients. Acta Haematol. 1959 Jun;21:346–359. [PubMed]
  • KAPLAN ME, JANDL JH. The effect of rheumatoid factors and of antigobulins of immune hemolysis in vivo. J Exp Med. 1963 Jan 1;117:105–125. [PMC free article] [PubMed]
  • WAGNER HN, Jr, RAZZAK MA, GAERTNER RA, CAINE WP, Jr, FEAGIN OT. Removal of erythrocytes from the circulation. Arch Intern Med. 1962 Jul;110:90–97. [PubMed]
  • BIERMAN HR, KELLY KH, CORDES FL, BYRON RL, Jr, POLHEMUS JA, RAPPOPORT S. The release of leukocytes and platelets from the pulmonary circulation by epinephrine. Blood. 1952 Jul;7(7):683–692. [PubMed]
  • GRIFONI V, SCALTRINI GC, CONFALONIERI C, CONIGLIARO S. [The adrenalin test in hematology]. Haematologica. 1959;44:393–420. [PubMed]
  • CHATTERJEA JB, DAMESHEK W, STEFANINI M. The adrenalin (epinephrin) test as applied to hematologic disorders. Blood. 1953 Mar;8(3):211–235. [PubMed]
  • WILSON SJ, EISEMANN G, CHANCE JH. The effect of the thrombocytopenic factor of idiopathic thrombocytopenic purpura on platelet levels as measured by direct and indirect methods. J Lab Clin Med. 1952 Oct;40(4):498–502. [PubMed]
  • HARRIS IM, MCALISTER JM, PRANKERD TA. The relationship of abnormal red cells to the normal spleen. Clin Sci (Lond) 1957 May;16(2):223–230. [PubMed]
  • TOGHILL PJ, PRICHARD BN. A STUDY OF THE ACTION OF NORADRENALINE ON THE SPLENIC RED CELL POOL. Clin Sci. 1964 Apr;26:203–212. [PubMed]
  • LEVIN RH, PERT JH, FREIREICH EJ. RESPONSE TO TRANSFUSION OF PLATELETS POOLED FROM MULTIPLE DONORS AND THE EFFECTS OF VARIOUS TECHNICS OF CONCENTRATING PLATELETS. Transfusion. 1965 Jan-Feb;5:54–63. [PubMed]
  • CRADDOCK CG, Jr, ADAMS WS, PERRY S, LAWRENCE JS. The dynamics of platelet production as studied by a depletion technique in normal and irradiated dogs. J Lab Clin Med. 1955 Jun;45(6):906–919. [PubMed]
  • NAJEAN Y, ARDAILLOU N, CAEN J, LARRIEU MJ, BERNARD J. SURVIVAL OF RADIOCHROMIUM-LABELED PLATELETS IN THROMBOCYTOPENIAS. Blood. 1963 Dec;22:718–732. [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...